Renal denervation beyond resistant hypertension treatment: current perspectives
https://doi.org/10.18705/1607-419X-2015-21-5-468-476
Abstract
Renal denervation is a novel promising approach for resistant hypertension management and it is getting more widespread. In recent years, this procedure has been studied not only as a method of additional reduction of blood pressure in non-responders to standard antihypertensive therapy, but also as a way of influencing other syndromes and diseases, which are related to sympathetic hyperactivity. The article provides a review of clinical trials of renal denervation in patients with insulin resistance and diabetes mellitus, left ventricular hypertrophy, heart failure, obstructive sleep apnea syndrome, atrial fibrillation and chronic kidney disease. Despite the controversial results of studies of renal denervation in patients with hypertension, there are more clinical data on the positive effect of the procedure on carbohydrate metabolism, left ventricular hypertrophy reduction and ejection fraction. The results of studies of renal denervation in patients with obstructive sleep apnea syndrome, as well as in patients with paroxysmal atrial fibrillation, are very interesting, though limited. There are more data on the safety of renal denervation in patients with chronic kidney disease. There are a lot of ongoing trials of renal denervation in different cohorts.
About the Authors
V. A. Sulimov
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
MD, PhD, Associate Professor, Department of Therapy № 1, Medical Faculty,
6/1 B. Pirogovskaya street, Moscow, 119991
A. V. Rodionov
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
MD, PhD, Associate Professor, Department of Therapy № 1, Medical Faculty,
6/1 B. Pirogovskaya street, Moscow, 119991
A. A. Svetankova
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
MD, PhD Student, Department of Therapy № 1, Medical Faculty,
6/1 B. Pirogovskaya street, Moscow, 119991
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Review
For citations:
Sulimov V.A., Rodionov A.V., Svetankova A.A. Renal denervation beyond resistant hypertension treatment: current perspectives. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2015;21(5):468-476. (In Russ.) https://doi.org/10.18705/1607-419X-2015-21-5-468-476
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