Express method for the salt sensitivity threshold determination
https://doi.org/10.18705/1607-419X-2015-21-5-487-492
Abstract
Background. To date, the response of blood pressure to the increased salt intake, which is considered to be a cardiovascular risk factor, and, in particular, arterial hypertension (HTN), is well investigated. The threshold of salt sensitivity (TSS) is a usual measure to assess the level of nutritional sodium intake. However, existing methods for evaluating nutritional sodium intake are difficult to implement in routine practice.
Objective. To develop a rapid method for the salt sensitivity threshold determination in clinical practice.
Design and methods. The first phase of the study was the comparison study of the developed method with test strips (12 and 3) and the Henkin’s method (12 sodium chloride solutions) in healthy volunteers. Depending on TSS all subjects were divided into 3 groups: low TSS — less than 0,16%, average — 0,16%, high — more than 0,16%. The second stage of the study included the TSS determination by the 12 test-strips in 40 men with masked HTN (1st group) and 59 men without diagnosed CVD (2nd group — healthy individuals).
Conclusions. Rapid method by the use of test strips is comparable with the original Henkin’s method, is easy to carry out and can be conducted using 12 or 3 test strips. TSS depends on age (increases in people older than 40 years) and on the presence of cardiovascular disease (for example, masked HTN).
About the Authors
V. P. Kulikov
Altai State Medical University
Russian Federation
Russian Federation
PhD, MD, Professor, Head, Department of Pathophysiology, Clinical Pathophysiology,
40 Lenina avenue, Barnaul, 656038
P. P. Tregub
Altai State Medical University
Russian Federation
Russian Federation
MD, PhD Student, Department of Pathophysiology and Clinical Pathophysiology,
40 Lenina avenue, Barnaul, 656038
I. V. Osipova
Altai State Medical University
Russian Federation
Russian Federation
PhD, MD, Professor, Head, Department of Therapy with Courses of Military-field Therapy, Immunology and Allergy,
40 Lenina avenue, Barnaul, 656038
A. I. Miroshnichenko
Clinical Hospital at the station Barnaul, Public Corporation “Russian Railways”
Russian Federation
Russian Federation
Head, Therapy Department,
Barnaul
A. V. Aleksentceva
Altai State Medical University
Russian Federation
Russian Federation
5th year student of the Medical Faculty, member of the youth science club,
40 Lenina avenue, Barnaul, 656038
References
1. Волков В.С., Поселюгина О.Б., Нилова С.А., Роккина С.А. Уровень артериального давления и потребление поваренной соли у больных артериальной гипертонией. Артериальная гипертензия. 2011;1:69–73. [Volkov VS, Poselyugina OB, Nilovа SA, Rokkina SA et al. The level of blood pressure and salt intake in patients with arterial hypertension. Arterial’naya Gipertenziya = Arterial Hypertension. 2011;17(1):69–73. In Russian].
2. Бабкин А.П., Гладких В.В. Роль поваренной соли в развитии артериальной гипертензии. Международный медицинский журнал. 2009;3:40–45. [Babkin AP, Gladkich VV. The role of salt in the development of hypertension. The International Medical Journal. 2009;3:40–45. In Russian].
3. Felder RA, White MJ, Williams SM, Jose PA. Diagnostic tools for hypertension and salt sensitivity testing. Curr Opin Nephrol Hypertens. 2013;22(1):65–76.
4. Aaron KJ, Sanders PW. Role of dietary salt and potassium intake in cardiovascular health and disease: a review of the evidence. Mayo Clin Proc. 2013;88(9):987–995.
5. Henkin RI, Gill JR, Bartter FC. Studies on taste threshold in normal man and in patients with adrenal cortisol insufficiency: the role of adrenal cortical steroids and serum concentration. J Clin Invest. 1963;42(5):727–735.
6. Технологии лабораторные клинические. Требования к качеству клинических лабораторных исследований. Часть 3. Правила оценки клинической информативности лабораторных тестов. ГОСТ Р 53022.3–2008, июль 2011 года. [Clinical Laboratory Technology. Requirements for the quality of clinical laboratory tests. Part 3: Rules assess the clinical information value of laboratory tests. GOST R 53022.3–2008, July 2011. In Russian].
7. Смирнова М.И., Оганов Р.Г., Горбунов В.М. Скрытая неэффективность лечения артериальной гипертонии: частота и предикторы. Кардиоваскулярная терапия и профилактика. 2011;10(6):11–17. [Smirnovа MI, Oganov RG, Gorbunov VM. Hidden ineffectiveness of treatment of hypertension: the frequency and predictors. Cardiovascular Therapy and Prevention. 2011;10 (6);11–17. In Russian].
8. Куликов В.П., Алексенцева А.В. Способ определения порога вкусовой чувствительности к поваренной соли. Патент России № 2539014.2013. Бюллетень № 1. [Kulikov VP, Aleksentseva AV. Method for determining the threshold of taste sensitivity to salt. Patent of Russia № 2539014.2013. Bulletin № 1. In Russian].
9. Поселюгина О.Б., Поселюгина Е.Б., Аль-Гальбан Н. Почему с возрастом учащается встречаемость артериальной гипертензии? Системные гипертензии. 2014;3:22–24. [Poselyugina OB, Poselyugina EB, Al-Gal'ban N. Why hypertension incidence increases with aging? Systemic hypertension. 2014;3:22–24. In Russian].
10. Осипова И.В., Мирошниченко А.И., Пырикова Н.В., Антропова О. Н., Куликов В. П., Алексенцева А. В. Долгосрочная вариабельность артериального давления и факторы риска у мужчин со стресс-индуцированной артериальной гипертензией. Артериальная гипертензия. 2014;20(2):92–100. [Osipova IV, Miroshnichenko AI, Pyrikova NV, Antropov ON, Kulikov VP, Aleksentseva AV. Long-term variability of blood pressure and risk factors in men with stress-induced hypertension. Arterial’naya Gipertenziya = Arterial Hypertension. 2014;20 (2):92–100. In Russian].
Review
For citations:
Kulikov V.P., Tregub P.P., Osipova I.V., Miroshnichenko A.I., Aleksentceva A.V. Express method for the salt sensitivity threshold determination. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2015;21(5):487-492. (In Russ.) https://doi.org/10.18705/1607-419X-2015-21-5-487-492
Views:
1667
Email this article 