Renovascular hypertension in kidney denervation
https://doi.org/10.18705/1607-419X-2015-21-6-552-558
Abstract
Objective. To determine the role of the sympathetic nervous system in the genesis of vasorenal hypertension.
Design and methods. In Wistar rats renovascular hypertension was created by renal artery (RA) clipping in the model of “two kidneys — one clip”.
Results. A stable blood pressure (BP) increase was observed only in
38 % of rats with clipped left RA. Preceding left kidney denervation did not prevent hypertension development, but successive transection of right renal nerve led to the decrease of BP in rats with vasorenal hypertension.
Conclusions. Based on our experiments, we suggest that different mechanisms are involved in the genesis of vasorenal hypertension, and changes in the activity of the sympathetic nervous system are important factors contributing to the BP increase as a result of afferent signals from ischemic kidneys.
About the Authors
V. A. Tsyrlin
V. A. Almazov Federal North-West Medical Research Centre, St Petersburg, Russia
First Pavlov State Medical University of St. Petersburg, St Petersburg, Russia
Saint-Petersburg State University, St Petersburg, Russia
Russian Federation
Russian Federation
MD, PhD, DSc, Professor, Leading Researcher, Department of Experimental Physiology and Pharmacology, V. A. Almazov North-West Medical Research Centre, Department of Pharmacology, First Pavlov State Medical University of St. Petersburg
2 Akkuratov street, St Petersburg, 197341 Russia
N. V. Kuzmenko
V. A. Almazov Federal North-West Medical Research Centre, St Petersburg, Russia
First Pavlov State Medical University of St. Petersburg, St Petersburg, Russia
Russian Federation
Russian Federation
PhD, Biology Sciences, Senior Researcher, Department of Experimental Physiology and Pharmacology, V. A. Almazov North-West Medical Research Centre, Laboratory of Circulation Biophysics, First Pavlov State Medical University of St. Petersburg
M. G. Pliss
V. A. Almazov Federal North-West Medical Research Centre, St Petersburg, Russia
First Pavlov State Medical University of St. Petersburg, St Petersburg, Russia
Russian Federation
Russian Federation
MD, PhD, Head, Department of Experimental Physiology and Pharmacology, V. A. Almazov North-West Medical Research Centre, Laboratory of Circulation Biophysics, First Pavlov State Medical University of St. Petersburg
N. S. Rubanova
V. A. Almazov Federal North-West Medical Research Centre, St Petersburg, Russia
First Pavlov State Medical University of St. Petersburg, St Petersburg, Russia
Russian Federation
Russian Federation
Junior Researcher, Department of Experimental Physiology and Pharmacology, V. A. Almazov North-West Medical Research Centre, Laboratory of Circulation Biophysics, First Pavlov State Medical University of St. Petersburg
References
1. Robertson JI, Morton JJ, Tillman DM, Lever AF. The pathophysiology of renovascular hypertension. J Hypertens. 1986;4 (suppl. 4): S95‑S103.
2. Dupont AG, Brouwers S. Btain angiotensin peptides regulate sympathetic tone and blood pressure. J Hypertens. 2010;28 (8):1599–1610.
3. Gao J, Zhang H, Le KD, Chao J, Gao L. Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats. Am J Hypertens. 2011;24 (6):724–730.
4. Stella A, Golin R, Genovesi S, Zanchetti A. Renal reflexes in the regulation of blood pressure and sodium excretion. Can J Physiol Pharmacol. 1987;65(8):1536–1539.
5. Kopp UC, Buckley-Bleiler RL. Impaired renorenal reflexes in two-kidney, one clip hypertensive rats. Hypertension. 1989;14(4):445–452.
6. Katholi RE, Winternitz SR, Oparil S. Role of the renal nerves in the pathogenesis of one-kidney renal hypertension in the rat. Hypertension. 1981;3(4):404–409.
7. Oparil S. The sympathetic nervous system in clinical and experimental hypertension. Kidney Int. 1986;30(3):437–452.
8. Osborn JW. Hypothesis: set-points and long-term control of arterial pressure. A theoretical argument for a long-term arterial pressure control system in the brain rather than the kidney. Clin Exper Pharmacol Physiol. 2005;32(5–6):384–393.
9. Wagner C, Hinder M, Krämer BK, Kurtz A. Role of renal nerves in the stimulation of the renin system by reduced renal arterial pressure. Hypertension. 1999;34(5):1101–1105.
10. Winternitz SR, Katholi RE, Oparil S. Decrease in hypothalamic norepinephrine content following renal denervation in the one-kidney, one clip Goldblatt hypertensive rat. Hypertension. 1982;4(3):369–373.
11. Wyss JM, Aboukarsh N, Oparil S. Sensory denervations of the kidney attenuates renovascular hypertension in the rat. Am J Physiol. 1986;250(1 Pt 2):H82–H86.
12. Tsyrlin VA, Galagudza MM, Kuzmenko NV, Pliss MG, Rubanova NS, Shcherbin YI. Arterial baroreceptor reflex counteracts long-term blood pressure increase in the rat model of renovascular hypertension. PLoS One. 2013;8(6): e64788. doi: 10.1371/journal.pone.0064788
13. Kalaitzis C, Touloupidis S, Bantis E, Patris E, Triantafyllidis A. Effects of renal denervation of the contralateral kidney on blood pressure and sodium and eicosanoid excretion in the chronic phase of two-kidney, one-clip renovascular hypertension in rats. Scand J Urol Nephrol. 2005;39(1):15–20.
14. Katholi RE, Whitlow PL, Winternitz SR, Oparil S. Importance of the renal nerves in established two-kidney, one clip Goldblatt hypertension. Hypertension. 1982;4(3):166–174.
15. Sato KL, doCarmo JM, Fazan VP. Ultrastructural anatomy of the renal nerves in rats. Drain Res. 2006;1119(1):94–100.
16. Brody MJ. New developments in our knowledge of blood pressure regulation. Fed Proc. 1981;40(8):2257–2261.
17. Cowley AW, Liard JF, Guyton AC. Role of the baroreceptor reflex in daily control of arterial blood pressure and other variables in dogs. Circul Res. 1973;32(5):564–577.
18. Di Rienzo M, Parati G, Castiglioni P, Omboni S, Ferrari AU, Ramirez AJ et al. Role of sinoaortic afferents in modulating BP and pulse-interval spectral characteristics in unanesthetized cats. Am J Physiol. 1991;261(6 Pt 2):1811–1818.
Review
For citations:
Tsyrlin V.A., Kuzmenko N.V., Pliss M.G., Rubanova N.S. Renovascular hypertension in kidney denervation. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2015;21(6):552-558. (In Russ.) https://doi.org/10.18705/1607-419X-2015-21-6-552-558
Views:
1575
Email this article 