Epigenetic mechanisms in hypertension and its complications
https://doi.org/10.18705/1607-419X-2015-21-6-559-566
Abstract
The discovery of the epigenetic regulation and the existence of trans-generation transfer of epigenetic changes became a revolutionary finding in modern medicine. These changes are mediated by environmental factors and lifestyle. The understanding of the underlying mechanisms elucidated pathogenesis of some non-infectious chronic pathologies including the diseases of musculoskeletal system, autoimmune diseases, tumors, psychiatric disorders, neurodegenerative disorders. Later, the epigenetic mechanisms were shown to play role in the development of cardiovascular diseases and diabetes mellitus. Nowadays the main, fundamental mechanisms of epigenetic regulation are established, and potential therapeutic approaches targeted at various epigenetic components are under development. This paper reviews different molecules that are studied and are approved. The studies in cardiovascular diseases are ongoing. Epigenetic mechanisms are involved in development of cardiovascular events, and other pathologies, as well as in regeneration of damaged organs and tissues, in the maintenance of pluripotent and regenerative characteristics of cell populations. Collected data will help to understand disease pathogenesis and to develop new prevention and treatment approaches.
About the Author
A. O. Konradi
V. A. Almazov Federal North-West Medical Research Centre, St Petersburg, Russia
Russian Federation
Russian Federation
MD, PhD, Professor, Deputy General Director on Research, V. A. Almazov Federal North-West Medical Research Centre.
2 Akkuratov street, St Petersburg, 197341 Russia. Phone: +7(812)702–37–33
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Review
For citations:
Konradi A.O. Epigenetic mechanisms in hypertension and its complications. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2015;21(6):559-566. (In Russ.) https://doi.org/10.18705/1607-419X-2015-21-6-559-566
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