Starvation in early life — possible influence on the further health. Case report
https://doi.org/10.18705/1607-419X-2015-21-6-639-645
Abstract
Conditions of early development largely determine the occurrence of chronic diseases in the remote life period. The impairment of perinatal nutrition could promote the development of metabolic disorders and cardiovascular complications in the adult life. Metabolic status, arterial stiffness, target organ damage and genetic biomarker (telomere length of peripheral leucocytes) are described in two patients who survived the Siege of Leningrad during the Second World War in different periods of life. First patient underwent starvation at the age of 19 years; second one was born during siege of Leningrad. Baseline visit at V. A. Almazov Federal North-West Medical Research Centre was performed in 2011, the follow-up visit — after 3 years in 2014. Results suggest that intrauterine starvation (also additional impact during infant period) is associated with more significant cardiovascular damage in second patient who was born in besieged Leningrad and was not evacuated. The clinical cases demonstrate the long-term effects of starvation in childhood and biomarkers of aging depending on starvation period.
About the Authors
E. V. Moguchaya
V. A. Almazov Federal North-West Medical Research Centre, St Petersburg, Russia
Russian Federation
Russian Federation
MD, Junior Researcher, Department for Epidemiology of Non-communicable Disease, V. A. Almazov Federal North-West Medical Research Centre
2 Akkuratov street, St Petersburg, 197341 Russia. Phone: +7(812)702–37–56
O. P. Rotar
V. A. Almazov Federal North-West Medical Research Centre, St Petersburg, Russia
Russian Federation
Russian Federation
MD, PhD, Head, Department for Epidemiology of Non-communicable Disease, V. A. Almazov Federal North-West Medical Research Centre
A. O. Konradi
V. A. Almazov Federal North-West Medical Research Centre, St Petersburg, Russia
Russian Federation
Russian Federation
MD, PhD, DSc, Professor, Head, Research Department for Hypertension, Deputy Director General on Research, V. A. Almazov Federal North-West Medical Research Centre
References
1. Barker DJ, Eriksson JG, Forsen T, Osmond C. Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol. 2002;31(6):1235–1239.
2. Могучая Е. В., Ротарь О. П., Конради А. О. Внутриутробное голодание и риск артериальной гипертензии и сердечно-сосудистых осложнений. Артериальная гипертензия. 2013;19 (4):299–304. [Moguchaya EV, Rotar OP, Konradi AO. Intrauterine undernutrition and hypertension and cardiovascular risk. Arterial’naya Gipertenziya = Arterial Hypertension. 2013;19 (4):299–304. In Russian].
3. Fontana L, Partridge L, Longo VD. Extending healthy life span-from yeast to humans. Science. 2010;328(5976):321–326.
4. Ротарь О. П., Могучая Е. В., Костарева А. А., Конради А. О. Теломеры: реальная связь с сердечно-сосудистыми заболеваниями или чрезмерные надежды? Российские Медицинские Вести. 2012; XVII(3):4–12. [Rotar OP, Moguchaya EV, Kostareva AA, Konradi AO. Telomeres: real association with cardiovascular diseases or inflated expectation? Rossiyskie Meditsinskie Vesti = Russian Medical News. 2012; XVII(3):4–12. In Russian].
5. Aviv A. Genetics of leukocyte telomere length and its role in atherosclerosis. Mutat Res. 2012;730(1–2):68–74.
6. Nilsson P, Boutouyrie P, Laurent S. Vascular aging: a tale of EVA and ADAM in cardiovascular risk assessment and prevention. Hypertension. 2009;54(1):3–10.
7. Jessica C, Kiefe DJ, Mathers JC, Franco OC. Nutrition and healthy ageing: the key ingredients. Proceed Nutr Soc. 2014;73 (2):249–259.
8. Rotar O, Moguchaya E, Boyarinova M, Kolesova E, Khromova N, Freylikhman O et al. 70 years after the Siege of Leningrad: does early life famine still affect cardiovascular risk and aging? J Hypertens. 2015;33(9):1772–1779.
9. Stanner SA, Bulmer K, Andres C, Lantseva OE, Borodina V, Poteen VV et al. Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study. Br Med J. 1997;315 (7119):1342–1348.
Review
For citations:
Moguchaya E.V., Rotar O.P., Konradi A.O. Starvation in early life — possible influence on the further health. Case report. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2015;21(6):639-645. (In Russ.) https://doi.org/10.18705/1607-419X-2015-21-6-639-645
Views:
1198
Email this article 