Preview

"Arterial’naya Gipertenziya" ("Arterial Hypertension")

Advanced search

Arterial hypertension incidence rates in a cohort of nuclear workers

https://doi.org/10.18705/1607-419X-2016-22-3-299-308

Abstract

Objective. To assess incidence rates for arterial hypertension (HTN) in the cohort of workers exposed occupationally to prolonged radiation.

Design and methods. Incidence of HTN was studied in the cohort of 22,377 workers of the first nuclear enterprise in the former USSR, the Mayak Production Association, for the entire follow-up period (1948–2008). “Crude” and standardized incidence rates were calculated. To standardize incidence rates indirect method was applied.

Results. As of 31.12.2008, 8,047 cases of HTN were registered in the study cohort (5,463 in males and 2,584 in females). Standardized incidence rates for HTN among workers of the study cohort were significantly associated with sex, attained age and body mass index. No relation was found between standardized incidence rates of HTN to occupational prolonged external gamma- ray-radiation.

Conclusions. Incidence of HTN in the cohort of nuclear workers was related to non-radiation factors, but had no association with occupational prolonged exposure.

About the Authors

K. V. Kuznetsova
Southern Urals Biophysics Institute, Ozyorsk, Russia 19 Ozyorskoe highway, Ozyorsk, Chelyabinskaya area, 456780 Russia. Phone: +7(35130)2–93–20. Fax: +7(35130)2–91–90
Russian Federation

MD, Junior Researcher, Southern Urals Biophysics Institute



T. V. Azizova
Southern Urals Biophysics Institute, Ozyorsk, Russia
Russian Federation

MD, PhD, Deputy Director on Science, Head, Clinical Department, Southern Urals Biophysics Institute



M. V. Bannikova
Southern Urals Biophysics Institute, Ozyorsk, Russia
Russian Federation

MD, Junior Researcher, Southern Urals Biophysics Institute



Ya. P. Bagaeva
Central Medical and Sanitary Unit № 71, Ozyorsk, Russia
Russian Federation

MD, Neurologist, Central Medical and Sanitary Unit № 71



N. P. Fotyeva
Central Medical and Sanitary Unit № 71, Ozyorsk, Russia
Russian Federation

MD, Physician, Central Medical and Sanitary Unit № 71



E. V. Azizova
Central Medical and Sanitary Unit № 71, Ozyorsk, Russia
Russian Federation

MD, Physician, Central Medical and Sanitary Unit № 71



References

1. ICRP (2007). 2007 Recommendations of the International Commission on Radiological Protection. ICRP Publication 103. Ann ICRP. 37(2–4).

2. United Nations Scientific Committee on the effects of Atomic Radiation (UNSCEAR) Biological mechanisms of radiation actions at low doses. UNSCEAR 2012 Report to the General Assembly, with scientific annexes. New York: United Nations. 2012;1:45 p.

3. Ozasa K, Shimizu Y, Suyama A, Kasagi F, Soda M, Grant EJ et al. Studies of the mortality of atomic bomb survivors, report 14, 1950–2003: an overview of cancer and non-cancer diseases. Radiat Res. 2012;177(3):229–243.

4. Клинические рекомендации по диагностике и лечению артериальной гипертонии. Евразийский кардиологический журнал. 2015;2:5–33. [Clinical recommendations on diagnostics and treatment of arterial hypertension. Evrazijskij Kardiologicheskij Zhurnal = Eurasian Cardiology Journal. 2015;2;5–33. In Russian].

5. Azizova TV, Day RD, Wald N, Muirhead CR, O’Hagan JA, Sumina MV et al. The “Clinic” medical-dosimetric database of Mayak production association workers: structure, characteristics and prospects of utilization. Health Phys. 2008;94(5):449–458.

6. Vasilenko EK, Scherpelz RI, Gorelov MV, Strom DJ, Smetanin MYu. External Dosimetry Reconstruction for Mayak Workers (2010) AAHP Special SessionHealth.http://www.hps1.org/aahp/public/AAHP_Special_Sessions/2010_Salt_Lake_City/pm‑1.pdf

7. Khokhryakov VV, Khokhryakov VF, Suslova KG, Vostrotin VV, Vvedensky VE, Sokolova AB et al. Mayak worker dosimetry system 2008 (MWDS‑2008): Assessment of internal dose from measurement results of plutonium activity in urine. Health Phys. 2013;104(4):366–378.

8. Мерков А. М., Поляков Л. Е. Санитарная статистика (пособие для врачей). М.: Атомиздат, 1974. 384 c. [Merkov AM, Poljakov LE. Sanitary statistics (guidelines for physicians). Moscow: Atomizdat, 1974. P. 384. In Russian].

9. Результаты второго этапа мониторинга эпидемиологической ситуации по артериальной гипертонии в РФ (2005–2007), проведенного в рамках Федеральной целевой программы «Профилактика и лечение артериальной гипертонии в РФ». Информационно-статистический сб. М., 2008. 224 с. [Results of the second stage of epidemiological monitoring on arterial hypertension in Russian Federation (2005–2007) within the Federal Target Program “Prevention and management of arterial hypertension in Russian Federation”. Information-statistical workbook. Moscow, 2008. P. 224. In Russian].

10. Wolf-Maier K, Cooper RS, Banegas JR, Giampaoli S, Hense HW, Joffres M et al. Hypertension prevalence and blood pressure levels in 6 European countries, Canada and the United States. J Am Med Assoc. 2003;289(18):2363–2369.

11. Маслова Н. П., Баранова Е. П. Гипертоническая болезнь у женщин. СПб.: издательство СПбГМУ, 2000. 78 c. [Maslova NP, Baranova EP. Hypertensive diseases among females. St Petersburg: Publishing House of St Petersburg State Medical University, 2000. P. 78. In Russian].

12. Langenickel T, Buttgereit J, Pagel I. Characterization of an animal model of menopausal hypertension in SHR. Hypertension. 2003;43(2):460–463.

13. Muscelli E, Kozakova M, Flyvbjerg A, Kyriakopoulou K, Astiarraga BD, Glintborg D et al. The effect of menopause on carotid artery remodeling, insulin sensitivity and plasma adiponectin in healthy women. Am J Hypertension. 2009;22(4):364–370.

14. Heart disease and stroke statistics — 2006 update: a report from the American Heart Association statistics committee and stroke statistics subcommittee. Circulation. 2006;113(6);85–151.

15. Franklin SS, Gustin W, Wong ND, Larson MG, Weber MA, Kannel WB et al. Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation. 1997;96 (1):308–315.

16. Hajjar I, Kotchen JM, Kotchen TA. Hypertension: trends in prevalence, incidence and control. Annu Rev Public Health. 2006;27:465–490.

17. Баланова Ю. А., Шальнова С. А., Деев А. Д., Константинов В. В., Капустина А. В. Артериальная гипертензия среду мужчин и женщин Москвы в различные временные периоды. Артериальная гипертензия. 2013;19(2):102–108. [Balanova YuA, Shal’nova SA, Deev AD, Konstantinova VV, Kapustina AV. Arterialhypertension among male and female citizens of Moscow in different calendar periods. Arterial’naya Gipertenziya = Arterial Hypertension. 2013;19(2):102–108. In Russian].

18. Khoo CM, Liew CF, Chew SK, Tai ES. The impact of central obesity as a prerequisite for the diagnosis of metabolic syndrome. Obesity (Silver Spring). 2007;15(1):262–269.

19. Stamler J, Rose G, Stamler R, Elliott P, Dyer A, Marmot M. INTERSALT study findings. Public health and medical care implications. Hypertension. 1989;14(5):570–577.

20. Жиров И. В., Винникова М. А., Агибалова Т. В. Алкоголь и женское сердце: влияние на сердечно-сосудистую заболеваемость и сердечно-сосудистый континуум. Сердце. 2006;5(7):364–367. [Zhirov IV, Vinnikova MA, Agibalova TV. Alcohol consumption and female heart: influence on cardiovascular incidence and cardiovascular continuum. Serdtse = Heart. 2006;5(7):364–367. In Russian].

21. Wilkinson B, Waring VS, Cockcroft DR. Hypertension. Translated from English. Budapest: Crew Kft. 2005;230 p.

22. Azizova TV, Haylock RGE, Moseeva MB, Bannikova MV, Grigoryeva ES. Cerebrovascular diseases incidence and mortality in an extended Mayak worker cohort 1948–1982. Radiation Research. 2014;182(5):529–544.

23. Shimizu Y, Kodama K, Nishi N, Kasagi F, Suyama A, Soda M et al. Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950–2003. Br Med J. 2010;340: b5349.

24. Yamada M, Wong FL, Fujiwara S, Akahoshi M, Suzuki G. Noncancer disease incidence in atomic bomb survivors, 1958–1998. Radiat Res. 2004;161(6):622–632.

25. Ivanov VK, Maksioutov MA, Chekin SY, Petrov AV, Biryukov AP, Kruglova ZG et al. The risk of radiation-induced cerebrovascular disease in Chernobyl emergency workers. Health Phys. 2006;90(3):199–207.

26. Shimizu Y, Pierce DA, Preston DL, Mabuchi K. 1999. Studies of the mortality of atomic bomb survivors. Report 12, part II. Noncancer mortality: 1950–1990. Radiat Res. 1999;152 (4):374–389.

27. Sasaki H, Wong FL, Yamada M, Kodama K. The effects of aging and radiation exposure on blood pressure levels of atomic bomb survivors. J Clin Epidemiol. 2002;55(10):974–981.

28. Azizova TV, Grigoryeva ES, Haylock RGE, Pikulina MV, Moseeva MB. Ischeamic heart disease incidence and mortality in an extended cohort of Mayak workers first employed in 1948–1982. Br J Radiol. 2015;88(1054):20150169.

29. Либов И. А., Киселев М. В., Смирнова В. Ю., Автандилов А. Г., Яковлев В. Н. Прогностическая роль эндотелина‑1 и возможности его коррекции у больных с нестабильной стенокардией. Русский медицинский журнал. 2008;16(4):211– 216. [Libov IA, Kiselev MV, Smirnova VYu, Avtandilov AG, Yakovlev VN. Prognostic role of endothelium and potential for its modification in patients with unstable angina. Russkij Meditsinskij Zhurnal = RMJ. 2008;16(4):211–216. In Russian].

30. Петрищев Н. Н., Васина Л. В., Власов Т. Д., Гавришева Н. Н. Типовые формы дисфункции эндотелия. Клинико-лабораторный консилиум. 2007;18:31–35. [Petrischev NN, Vasina LV, Vlasov TD, Gavrisheva NN. Kliniko-laboratornyj Konsilium = Clinical and Laboratory Consilium. 2007;18:31–35. In Russian].

31. Небиеридзе Д. В. Клиническое значение дисфункции эндотелия при артериальной гипертонии. Системные гипертензии. 2005;7(1):31–38. [Nebieridze DV. Clinical implication of endothelial dysfunction associated with arterial hypertension.Sistemnye Gipertenzii = System Hypertension. 2005;7(1):31–38. In Russian].

32. Шляхто Е. В., Моисеева О. М., Лясникова Е. А., Виллевальде С. В., Емельянов И. В. Реологические свойства крови и функция эндотелия у больных гипертонической болезнью. Кардиология. 2004;44(4):20–23. [Shlyakhto EV, Moiseeva OM, Lyasnikova EA, Villevalde SV, Emelyanov IV. Rheological properties of blood and endothelial function in atients with hypertensive disease. Kardiologiia. 2004;44(4):20–23. In Russian].

33. McKinney LC, Aquilla EM, Coffin D, Wink DA, Vodovotz Y et al. Ionizing radiation potentiates the induction of nitric oxide synthase by IFN-g and/or LPS in murine macrophage cell lines: role of TNF-a. J Leukoc Biol. 1998;64(4):459–466.

34. Lanza V, Fadda P, Iannone C, Negri R. Low-dose ionizing radiation stimulates transcription and production of endothelin by human vein endothelial cells. Radiat Res. 2007;168(2):193–198.

35. Vardar SA, Gunduz O, Altun GD, Aydogdu N, Karadag H, Torun N et al. The alteration of asymmetric dimetilarginine (ADMA) levels in cardiac and gastrocnemius muscles following radioactive iodine application in guinea pigs and the effect of L‑carnitine on this alteration. Int J Radiat Biol. 2011;87(1):2–7.


Review

For citations:


Kuznetsova K.V., Azizova T.V., Bannikova M.V., Bagaeva Ya.P., Fotyeva N.P., Azizova E.V. Arterial hypertension incidence rates in a cohort of nuclear workers. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2016;22(3):299-308. (In Russ.) https://doi.org/10.18705/1607-419X-2016-22-3-299-308

Views: 1471


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1607-419X (Print)
ISSN 2411-8524 (Online)