Поражение почек при артериальной гипертензии: можем ли мы доверять старым маркерам?
https://doi.org/10.18705/1607-419X-2016-22-6-536-550
Аннотация
В связи с высокой распространенностью хронической болезни почек (ХБП) в настоящее время, а также рядом недостатков традиционных параметров оценки почечной функции в последние несколько лет все больше внимания уделяется поиску новых маркеров поражения почек для более ранней и точной диагностики начала ХБП. В представленном обзоре приведены данные литературы о традиционных маркерах поражения почек в сравнении с новыми биохимическими маркерами, отражающими в основном тубулоинтерстициальное повреждение почек, происходящее на более ранних этапах поражения почек, проанализирована возможность использования ряда биомаркеров, таких как липокалин, ассоциированный с желатиназой нейтрофилов, молекула почечного повреждения, цистатин С и печеночная форма белка, связывающая жирные кислоты, в ранней диагностике как острого, так и хронического поражения почек, в том числе при гипертензивной нефропатии.
Об авторах
С. А. Миронова
Федеральное государственное бюджетное учреждение «Северо-Западный федеральный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации
Россия
Россия
аспирант очной формы обучения научно-исследовательской лаборатории (НИЛ) патогенеза и терапии артериальной гипертензии научно-исследовательского отдела артериальной гипертензии (НИО АГ),
ул. Аккуратова, д. 2, Санкт-Петербург, 197341
Н. Э. Звартау
Федеральное государственное бюджетное учреждение «Северо-Западный федеральный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации;
Университет ИТМО
Россия
Россия
кандидат медицинских наук, старший научный сотрудник НИЛ патогенеза и терапии артериальной гипертензии НИО АГ;
старший научный сотрудник,
Санкт-Петербург
А. О. Конради
Федеральное государственное бюджетное учреждение «Северо-Западный федеральный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации;
Университет ИТМО
Россия
Россия
доктор медицинских наук, профессор, руководитель НИО АГ, заместитель генерального директора по научной работе;
директор Института трансляционной медицины, руководитель международной лаборатории «Системы поддержки принятия решений в медицине»,
Санкт-Петербург
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Рецензия
Для цитирования:
Миронова С.А., Звартау Н.Э., Конради А.О. Поражение почек при артериальной гипертензии: можем ли мы доверять старым маркерам? Артериальная гипертензия. 2016;22(6):536-550. https://doi.org/10.18705/1607-419X-2016-22-6-536-550
For citation:
Mironova S.A., Zvartau N.E., Konradi A.O. Kidney injury in arterial hypertension: can we trust the old markers? "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2016;22(6):536-550. (In Russ.) https://doi.org/10.18705/1607-419X-2016-22-6-536-550
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