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Артериальная гипертензия

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Артериальная гипертония как кардиотоксическая реакция на противоопухолевую терапию: что мы знаем о новом виде ятрогенной гипертонии

https://doi.org/10.18705/1607-419X-2018-24-4-384-395

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Аннотация

Одним из ключевых регуляторов сосудистого тонуса является фактор роста эндотелия сосудов (VEGF), способный усиливать продукцию оксида азота, мощного вазодилататора, и уменьшать сосудистое сопротивление посредством генерации новых сосудов микроциркуляторного русла. Оба эти механизма способствуют снижению артериального давления. Появление нового класса противоопухолевой терапии — ингибиторов ангиогенеза — закономерно привело к росту такой нежелательной реакции, как артериальная гипертензия (АГ). Целью данной публикации является анализ причин развития АГ, подходов к своевременной диагностике АГ и корректной оценке сердечно-сосудистого риска — как при планировании, так и на фоне терапии ингибиторами ангиогенеза, особенностям коррекции АГ у пациентов, получающих таргетную терапию.

Об авторах

Ж. Д. Кобалава
Федеральное государственное автономное образовательное учреждение высшего образования «Российский университет дружбы народов»
Россия

д.м.н., профессор, заведующая кафедрой пропедевтики внутренних болезней РУДН

ул. Миклухо-Маклая, д. 6, Москва, Россия, 117198



Е. К. Шаварова
Федеральное государственное автономное образовательное учреждение высшего образования «Российский университет дружбы народов»
Россия

к.м.н., доцент кафедры внутренних болезней с курсом кардиологии и функциональной диагностики РУДН

ул. Миклухо-Маклая, д. 6, Москва, Россия, 117198



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Для цитирования:


Кобалава Ж.Д., Шаварова Е.К. Артериальная гипертония как кардиотоксическая реакция на противоопухолевую терапию: что мы знаем о новом виде ятрогенной гипертонии. Артериальная гипертензия. 2018;24(4):384-395. https://doi.org/10.18705/1607-419X-2018-24-4-384-395

For citation:


Kobalava Z.D., Shavarova E.K. Hypertension related to the antitumor treatment with angiogenesis inhibitors: an iatrogenic hypertension. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2018;24(4):384-395. (In Russ.) https://doi.org/10.18705/1607-419X-2018-24-4-384-395

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ISSN 1607-419X (Print)
ISSN 2411-8524 (Online)