Preview

"Arterial’naya Gipertenziya" ("Arterial Hypertension")

Advanced search

RISK ASSESSMENT OF CARDIOVASCULAR COMPLICATIONS IN “WHITE COAT” HYPERTENSION

https://doi.org/10.18705/1607-419X-2017-23-1-47-55

Abstract

Objective. To detect the frequency of “white coat” hypertension (WCH) in 40–49-year old men and its association with the indicators of cardiovascular remodeling and cardiovascular risk factors. design and methods. In a single-step study, we assessed cardiovascular risk in 350 men (40–49 years old) with different levels of blood pressure (BP) based on the 24-hour ambulatory BP monitoring (ABPM).

Results. Prevalence of left ventricular hypertrophy (LVH) was 8 % in patients with WCH, and 26 % in patients with high BP (χ 2 = 4,9, p < 0,05). The rate of increased intima-media thickness more than 0.9 mm was 11 % in WCH group, compared to 28 % among patients with verified arterial hypertension (HTN) (χ 2 = 3,9; p < 0,05). Compared with healthy cohort, left ventricular myocardial mass index and carotid artery wall thicknesses were significantly higher in patients with LVH.

Conclusions. The prevalence of the WCH among 40–49-year-old hypertensive men was 36 %. The prevalence of risk factors, lipid metabolic disorders is lower in patients with WCH compared to patients with high BP verified by ABPM. Normal ABPM indices are associated with lower LVH frequency and vascular remodeling. Hypertensive remodeling is more profound in patients with WCH compared 

About the Authors

E. A. Grigoricheva
South Ural State Medical University
Russian Federation

Elena A. Grigoricheva - MD, PhD, DSc, Professor, Department for Out-patient Therapy and Clinical Pharmacology, Head, Department for Functional Diagnostics.

64 Vorovskyi street, Chelyabinsk, 454076



Yu. L. Bondareva
PHILIPS, LLC
Russian Federation
Yuliya L. Bondareva - Equipment Specialist


O. N. Kolomeychuk
Hospital of Kurgan Railway Station
Russian Federation
Olga N. Kolomeychuk - MD, Department for Functional Diagnostics


References

1. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. J Am Med Assoc. 2003;289 (19):2560–72.

2. Mancia G, Ferrari A, Gregorini L, Parati G, Pomidossi G, Bertinieri G et al. Blood pressure and heart rate variabilities in normotensive and hypertensive human beings. Circ Res. 1983;53 (1):96–104.

3. Verdecchia P, Porcellati C, Schillaci G, Borgioni C, Ciucci A, Battistelli M et al. Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension. Hypertension. 1994;24(6):793–801.

4. Pierdomenico SD, Lapenna D, Bucci A, Manente BM, Mancini M, Cuccurullo F et al. Blood pressure variability and prognosis in uncomplicated mild hypertension. Am Heart J. 2005;149(5):934–8.

5. Kario K, Pickering TG, Matsuo T, Hoshide S, Schwartz JE, Shimada K. Stroke prognosis and abnormal nocturnal blood pressure falls in older hypertensives. Hypertension. 2001;38(4): 852–7.

6. Palatini P, Mormino P, Santonastaso M, Mos L, Follo M Dal, Zanata G. Target-Organ Damage in Stage I Hypertensive Subjects With White Coat and Sustained Hypertension Results From the HARVEST Study. Hypertension. 1998;31(1):57–63.

7. Verdecchia P, Reboldi GP, Angeli F, Schillaci G, Schwartz JE, Pickering TG et al. Shortand long-term incidence of stroke in white-coat hypertension. Hypertension. 2005;45(2):203–8.

8. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2013;31 (7):1281–1357.

9. O’Brien F, Owens P, Petrie J, Petrie J, Padfield PL, Littler WA et al. Use and interpretation of ambulatory blood pressure monitoring: recommendations of the British Hypertension Society. Br Med J. 2000;320(7242):1128–1134.

10. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992;340(8828):1111–1115.

11. Затейщиков Д. А., Минушкина Л. О., Кудряшова О. Ю., Баринов В. К., Цымбалова Т. Е., Носенко Е. М. и др. Функциональное состояние эндотелия у больных артериальной гипертонией и ИБС. Кардиология. 2000;40 (6):14–17. [Zatejshchikov DA, Minushkina LO, Kudryashova OYu, Barinov VK, Tsymbalova TE, Nosenko EM et al. Endothelial function in patients with arterial hypertension and coronary heart disease. Kardiologiia. 2000;40(6): 14–17. In Russian].

12. Затейщикова А. А., Затейщиков Д. А. Эндотелиальная регуляция сосудистого тонуса: методы исследования и клиническое значение. Кардиология. 1998;38(9):68–78. [Zatejshchikova AA, Zatejshchikov DA. Endothelial regulation of vascular tone: research methods and clinical significance. Kardiologiia. 1998;38(9):68–78. In Russian].

13. Vogel R. Coronary risk factors, endothelial function and atherosclerosis: a review. Clin Cardioloogy. 1997;20(5):426–432.

14. Горбунов В. М. Некоторые вопросы практического использования суточного мониторирования артериального давления. Клиницист. 2008;3(3):30–40. [Gorbunov VM. Some issues of practical use of 24-hour blood pressure monitoring. Klinitsist = Clinician. 2008;3(3):30–40. In Russian].

15. Кобалава Ж. Д., Котовская Ю. В., Кобзев Р. Ю. Фенотипы артериального давления у молодых мужчин. Кардиология. 2009;12(49):23–28. [Kobalava ZhD, Kotovskaya YuV, Kobzev RYu. Phenotypes of arterial pressure in young men. Kardiologiia. 2009;12(49):23–28. In Russian].

16. Котовская Ю. В., Кобалава Ж. Д. Амбулаторные методы регистрации артериального давления в клинической практике. Евразийский кардиологический журнал. 2015;3:38–44. [Kotovskaya YuV, Kobalava JD. Out-patient methods of registration of blood pressure in clinical practice. Evraziyskiy Kardiologicheskiy Zhurnal = Eurasian Heart Journal. 2015;3:38–44. In Russian].

17. Бритов А. Н., Платонова Е. М., Смирнова М. И., Горбунов В. М., Елисеева Н. А., Рыжова Т. В. и др. Морфофункциональные показатели миокарда у больных со скрытой артериальной гипертонией и «гипертонией белого халата». Клиническая медицина. 2015;10(93):31–38. [Britov AN, Platonova EM, Smirnova MI, Gorbunov VM, Eliseeva NA, Ryzhova TV et al. Morpho-functional myocardial characteristics in patients with masked arterial hypertension and “white coat” hypertension. Klinicheskaya Meditsina = Clinical Medicine. 2015;10(93):31–38. In Russian].

18. Staessen JA, O’Brien ET, Amery AK, Atkins N, Baumgart P, De Cort P et al. Ambulatory blood pressure in normotensive and hypertensive subjects: results from an international database. J Hypertens. Suppl. 1994;12(7):S1–12.

19. Dolan E, Stanton A, Atkins N, Den Hond E, Thijs L, McCormack P et al. Determinants of white-coat hypertension. Blood Press Monit. 2004;9(6):307–309.

20. Mancia G, Facchetti R, Bombelli M, Grassi G, Sega R. Long-term risk of mortality associated with selective and combined elevation in office, home and ambulatory blood pressure. Hypertension. 2006;47(5):846–853.

21. Fagard RH, Cornelissen VA. Incidence of cardiovascular events in white-coat, masked and sustained hypertension versus true normotension: a meta-analysis. J Hypertens. 2007;25(11): 2193–2198.

22. Pierdomenico SD, Cuccurullo F. Prognostic value of white-coat and masked hypertension diagnosed by ambulatory monitoring in initially untreated subjects: an updated meta-analysis. Am J Hypertens. 2011;24(1):52–58.

23. Franklin SS, Thijs L, Hansen TW, Li Y, Boggia J, Kikuya M et al. Significance of white-coat hypertension in older persons with isolated systolic hypertension: a meta-analysis using the International Database on ambulatory blood pressure monitoring in relation to cardiovascular outcomes population. Hypertension. 2012;59(3):564–571.


Review

For citations:


Grigoricheva E.A., Bondareva Yu.L., Kolomeychuk O.N. RISK ASSESSMENT OF CARDIOVASCULAR COMPLICATIONS IN “WHITE COAT” HYPERTENSION. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2017;23(1):47-55. (In Russ.) https://doi.org/10.18705/1607-419X-2017-23-1-47-55

Views: 1289


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1607-419X (Print)
ISSN 2411-8524 (Online)