HORMONAL STATUS, STRUCTURAL AND FUNCTIONAL CHARACTERISTICS OF THE MYOCARDIUM IN PATIENTS WITH ACROMEGALY AND ARTERIAL HYPERTENSION

Objective. To assess the features of the cardiovascular system and hormonal regulation of acromegaly in patients with arterial hypertension (HTN). design and methods. The study involved 66 patients with acromegaly. We assessed the interrelations between hormonal and cardiovascular parameters in acromegaly and HTN. Results. The main cardiovascular disorders in patients with acromegaly and HTN include concentric hypertrophy and left ventricular diastolic dysfunction, dilatation of the left atrium, and abnormal daily blood pressure (BP) profile. conclusions. The increased serum levels of growth hormone and insulin-like growth factor 1, duration of acromegaly and functional activity of a pituitary-adrenal axis are associated with the abnormal daily BP variability, contractile dysfunction of the longitudinal fibers of the left ventricular myocardium, reduced velocity of active relaxation of the left atrium, and left ventricular hypertrophy.

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