KNEE OSTEOARTHRITIS: INFLUENCE ON CIRCADIAN BLOOD PRESSURE PROFILE IN POSTMENOPAUSAL WOMEN

Objective. To assess features of circadian blood pressure profile in ambulatory female patients with knee osteoarthritis (OA). design and methods. In case control study 60 postmenopausal female out-patients were recruited from those undergoing ambulatory blood pressure monitoring (ABPM). All patients signed the informed consent. All women had arterial hypertension (HTN) with no antihypertensive treatment reported by the inclusion date. Main group (30 women, median age 58 years; 25–75 %: 55,0–61,0) had HTN and OA. Control group (30 women, median age 56 years; 25–75 %: 52,0–60,0) had HTN and no OA criteria. Results. Office blood pressure (BP) did not differ between the groups. However, ABPM showed higher average BP in the group with OA. Higher time index for both systolic BP (SBP) and diastolic BP (DBP) during daytime and nighttime, SBP and DBP higher variability, as well as insufficient nighttime PB decrease were found in OA patients. conclusions. Our findings provide additional explanation of the target organ involvement in hypertensive postmenopausal women and confirm the need to perform ABPM in hypertensive OA patients.

osteoarthritis, comorbidity, chronic pain, females, menopause, arterial hypertension, ambulatory blood pressure monitoring

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