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Артериальная гипертензия

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ГЕНДЕРНЫЕ РАЗЛИЧИЯ В ПРОЯВЛЕНИИ ЛЕГОЧНОЙ ГИПЕРТЕНЗИИ. ВЛИЯНИЕ ЖЕНСКОГО ПОЛОВОГО ГОРМОНА ЭСТРАДИОЛА

https://doi.org/10.18705/1607-419X-2017-23-5-421-432

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Аннотация

Легочная гипертензия (ЛГ) — группа гетерогенных заболеваний, отличающихся своей этиологией и фенотипом, но объединенных основными симптомами заболевания — повышением артериального давления в малом круге кровообращения и гипертрофией правого желудочка сердца. Важной особенностью всех типов ЛГ является гендерная зависимость в проявлении этого заболевания. Согласно клиническим данным женская часть населения в большей степени подвержена ЛГ, что противоречит представлениям о протективном действии женского полового гормона. Это явление получило название эстрадиолового парадокса. В обзоре обсуждаются возможные механизмы гендерных различий в проявлении ЛГ, сравниваются экспериментальные данные, полученные на животных, с результатами клинических исследований, анализируются геномный и негеномный эффект действия эстрадиола на состояние сердечнососудистой системы, возможное участие метаболитов эстрадиола и механизмы гипертрофии правого желудочка сердца.

Об авторах

Н. А. Медведева
Федеральное государственное бюджетное   образовательное учреждение высшего образования   «Московский государственный университет   имени М. В. Ломоносова».
Россия
Медведева Наталия Александровна — доктор биологических наук, профессор, ведущий научный сотрудник кафедры физиологии человека и животных биологического ф-та ФГБУ ВПО МГУ им. М. В. Ломоносова. Ленинские горы, д. 1, Москва, 119991.


Н. В. Панькова
Федеральное государственное бюджетное   образовательное учреждение высшего образования   «Московский государственный университет   имени М. В. Ломоносова».
Россия
Панькова Надежда Владимировна — аспирант кафедры физиологии человека и животных биологического ф-та ФГБУ ВПО МГУ им. М. В. Ломоносова. Москва.


М. М. Артемьева
Федеральное государственное бюджетное   образовательное учреждение высшего образования   «Московский государственный университет   имени М. В. Ломоносова».
Россия

Артемьева Марина Михайловна — кандидат биологических наук, научный сотрудник кафедры физиологии человека и животных биологического ф-та ФГБУ ВПО МГУ им. М. В. Ломоносова.

Москва.



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Для цитирования:


Медведева Н.А., Панькова Н.В., Артемьева М.М. ГЕНДЕРНЫЕ РАЗЛИЧИЯ В ПРОЯВЛЕНИИ ЛЕГОЧНОЙ ГИПЕРТЕНЗИИ. ВЛИЯНИЕ ЖЕНСКОГО ПОЛОВОГО ГОРМОНА ЭСТРАДИОЛА. Артериальная гипертензия. 2017;23(5):421-432. https://doi.org/10.18705/1607-419X-2017-23-5-421-432

For citation:


Medvedeva N.A., Pankova N.V., Artemieva M.A. GENDER DIFFERENCES IN THE DEVELOPMENT OF PULMONARY HYPERTENSION: EFFECTS OF FEMALE SEX HORMONE ESTRADIOL. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2017;23(5):421-432. (In Russ.) https://doi.org/10.18705/1607-419X-2017-23-5-421-432

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ISSN 1607-419X (Print)
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