Рredictors and markers of experimental vasorenal hypertension onset in the model “2 kidneys, 1 clamp”

The aim of the study was to analyze the influence of the baseline systolic blood pressure (SBP), the length of beat-to-beat interval (RR) and the components of the heart rate variability (HRV) spectrum on the development of vasorenal hypertension in the model “2 kidneys, 1 clamp” in Wistar rats. Also we investigated the relationship between anxiety and parameters of hemodynamics in intact animals using the “open field” test and the correlations between SBP level, RR duration and the components of the HRV spectrum in both intact animals and animals with renal artery ischemia. Design and methods. We recorded hemodynamic parameters on the tail of awake rats. In the HRV analysis, a low-frequency component (LF), a high-frequency component (HF) and a sympathetic-vagal balance (LF/HF) were calculated. Results. In normotensive rats the normal high SBP is accompanied by tachycardia and increased anxiety in “open field” test. The baseline values of SBP, RR interval and HRV spectrum components do not influence the development of unilateral vasorenal hypertension. In the development of unilateral vasorenal hypertension, weakened parasympathetic effects on cardiac function were observed, as evidenced by a decrease in the RR interval duration and HF component of the HRV spectrum in animals with developed hypertension, as well as an increase in the LF/HF component of HRV in clamped rats. Сonclusions. Individual increased anxiety of normotensive animals does not affect the development of vasorenal hypertension in the model “2 kidneys, 1 clamp”.

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