EXPRESSION OF NAP 22 MRNA IN KIDNEY OF SPONTANEOUSLY HYPERTENSIVE RATS (SHR LINE) AND NORMOTENSIVE RATS (WKY LINE) IN EARLY POSTNATAL ONTOGENESIS UNDER NORMAL EXOGENOUS CALCIUM INTAKE AND ITS DEFICIT
https://doi.org/10.18705/1607-419X-2014-20-5-401-405
Abstract
In kidney of spontaneously hypertensive rats in early postnatal ontogenesis, we studied the changes in the expression of NAP-22 quantitatively predominant protein kinase C substrate mRNA, which served us as an indicator of the severity of disruption in cell apparatus. Exogenous calcium deficiency increased the expression of NAP-22 mRNA. Based on the changes in the expression level of this protein, it can be resumed that disorders of kidney function precede the formation of lasting hypertension in the animals.
About the Authors
A. S. Aldekeeva
Pavlov Institute of Physiology of Russian Academy of Sciences, St Petersburg.
The Institute of Analytical Instrument Making, St Petersburg
Russian Federation
Russian Federation
N. A. Korneva
The Institute of Analytical Instrument Making, St Petersburg
Russian Federation
Russian Federation
E. D. Rudenko
The Institute of Analytical Instrument Making, St Petersburg
Russian Federation
Russian Federation
N. Z. Klueva
Pavlov Institute of Physiology of Russian Academy of Sciences, St Petersburg
Russian Federation
Russian Federation
Corresponding author: Pavlov Institute of Physiology of Russian Academy of Sciences, 6 Makarov emb., St Petersburg, Russia 199034. E-mail: natklueva@mail.ru (Natalia Z. Klueva, Candidate of Biology, the Senior Researcher at the Laboratory of Experimental and Clinical Cardiology at Pavlov Institute of Physiology of Russian Academy of Sciences).
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Review
For citations:
Aldekeeva A.S., Korneva N.A., Rudenko E.D., Klueva N.Z. EXPRESSION OF NAP 22 MRNA IN KIDNEY OF SPONTANEOUSLY HYPERTENSIVE RATS (SHR LINE) AND NORMOTENSIVE RATS (WKY LINE) IN EARLY POSTNATAL ONTOGENESIS UNDER NORMAL EXOGENOUS CALCIUM INTAKE AND ITS DEFICIT. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2014;20(5):401-405. https://doi.org/10.18705/1607-419X-2014-20-5-401-405
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