DISORDERS OF LEFT VENTRICULAR DIASTOLIC FUNCTION AND ANTHROPOMETRIC PARAMETERS IN PATIENTS WITH ABDOMINAL OBESITY

Objective. To evaluate diastolic function of the left ventricle and anthropometric parameters in patients with abdominal obesity (AO). Design and methods. We examined 438 patients aged 30 to 55 years (44,8 ± 0,3 years) with AO (IDF, 2005) and 115 patients (40,3 ± 0,8 years) without AO (comparison group). Two-dimensional transthoracic echocardiography was performed (GE Vivid 7 Dimension) in 2D mode, in M-mode, also Doppler studies were performed using pulsed, continuous-wave, color and tissue regimes of Doppler. Results. Based on echocardiography, 126 patients with AO and arterial hypertension (HTN) (28,8 %) (94 women and 32 men) had type I left ventricular diastolic dysfunction (LVDD). In patients with AO and without HTN, the E/A ratio and the E’ value were lower, and the DT and isovolumic relaxation time (IVRT), the E/E’ and LAVI ratio are higher than the same parameters in the comparison group (p < 0,0001). Only the ratio E/E’ was in accordance with the criteria for type 1 LVDD. We found positive correlations between the body mass index (BMI) and the IVRT (r = 0,3, p = 0,0001), BMI and the E/E’ ratio (r = 0,4, p = 0,0001), BMI and LAVI (r = 0,4, p = 0,0001), between the waist circumference (WC) and the IVRT (r = 0,3, p = 0,001), the WC and the E/E’ (r = 0,3, p = 0,0001), WC and LAVI (r = 0,4, p = 0,0001) in female with AO without HTN. In patients with AO and without HTN, there is a 3,7-fold increase in LVDD risk in case of BMI ≥ 30,0 kg/m 2 (odds ratio: 3,7, 95 % confidence interval: 1,2–9,0, p < 0,0001). Conclusions. The type I LVDD was found in patients with AO and HTN. in patients with AO without concomitant HTN, the risk of LVDD increases by 3,7 times with a threshold of body mass index ≥ 30,0 kg/m 2.

abdominal obesity, diastolic dysfunction, body mass index, waist circumference, echocardiography

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