GALECTIN 3 IN PATIENTS WITH METABOLIC SYNDROME AND ATRIAL FIBRILLATION
https://doi.org/10.18705/1607-419X-2014-20-5-462-469
Abstract
fibrillation (AF) and to reveal the significance of this marker of fibrosis in MS.
Design and methods. We examined 100 patients with MS (50 with paroxysmal or persistent AF and 50 without arrhythmia) and 50 healthy persons. Serum galectin 3 was measured by ELISA method, all examined subjects underwent echocardiography.
Results. Galectin 3 was higher in patients with MS and AF compared to patients with MS without arrhythmia and much higher than in healthy persons [0,72 (0,44; 1,36); 0,44 (0,42; 1,22 and 0,32 (0,28; 0,42) ng/ml, р < 0,05; р < 0,001 and р < 0,001, respectively]. Galectin 3 in patients with 5 components of MS was higher, than in patients with 4 and 3 components of MS [2,01 (0,52; 4,59); 0,54 (0,44; 1,37) and 0,42 (0,32; 0,42) ng/ml, р < 0,05; р < 0/001 and р < 0,001, respectively]. Correlations between galectin 3 and waist circumference, blood pressure, left and right atrium volume, triglyceride level were found (r = 0,57; r = 0,51; r = 0,45; r = 0,40; r = 0,41; р < 0,001).
Conclusion. Galectin 3, a marker of fibrosis in patients with MS and atrial fibrillation was higher than in patients with MS without arrhythmia and significantly higher than in healthy persons.
About the Authors
V. A. Ionin
First Pavlov State Medical University of St. Petersburg, St Petersburg
Russian Federation
Corresponding author: First Pavlov State Medical University of St. Petersburg, 6–8 L. Tolstoy street, St Petersburg, Russia, 197022. Е-mail: ionin.v.a@gmail.com (Valeriy A. Ionin, MD, an Assistant at the Department of Internal Diseases № 1 at the First Pavlov State Medical University of St. Petersburg).
Russian Federation
Corresponding author: First Pavlov State Medical University of St. Petersburg, 6–8 L. Tolstoy street, St Petersburg, Russia, 197022. Е-mail: ionin.v.a@gmail.com (Valeriy A. Ionin, MD, an Assistant at the Department of Internal Diseases № 1 at the First Pavlov State Medical University of St. Petersburg).
O. V. Listopad
First Pavlov State Medical University of St. Petersburg, St Petersburg
Russian Federation
Russian Federation
S. E. Nifontov
First Pavlov State Medical University of St. Petersburg, St Petersburg
Russian Federation
Russian Federation
E,. Yu. Vasiljeva
First Pavlov State Medical University of StFederal Almazov Medical Research Centre, St Petersburg. Petersburg, St Petersburg
Russian Federation
Russian Federation
A. V. Soboleva
First Pavlov State Medical University of St. Petersburg, St Petersburg
Russian Federation
Russian Federation
O. D. Belyaeva
Federal Almazov Medical Research Centre, St Petersburg
Russian Federation
Russian Federation
E. I. Baranova
First Pavlov State Medical University of St. Petersburg, St Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Ionin V.A., Listopad O.V., Nifontov S.E., Vasiljeva E.Yu., Soboleva A.V., Belyaeva O.D., Baranova E.I. GALECTIN 3 IN PATIENTS WITH METABOLIC SYNDROME AND ATRIAL FIBRILLATION. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2014;20(5):462-469. https://doi.org/10.18705/1607-419X-2014-20-5-462-469
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