Impact of insertion-deletion polymorphism of angiotensin-convcrting enzyme gene on the development and progression of diabetic nephropathy and efficiency of its therapy in patients with type 1 diabetes mellitus

The study was undertaken to examine the association of the insertion-detection (ID) polymorphism of angiotensin-converting enzyme (ACE) gene with the development and progression oJ diabetic nephropathy (DN) and to establish a relationship of different allele types of genetic- polymorphism to the efficiency of microalbuminuria (MAU) diminution in captopril-treated patients with evolving DN. The study of the I/D polymorphism of ACE gene revealed no statistical differences in the distribution of genotypes and alleles in the group of patients with (n = 17) and without (n = 79) DN. However, the significantly higher frequency of D allele was found in patients with end-stage DN (significant nephropathy and uremia) as compared with those of early-stage DN (MAU) (p<0,05). The revealed regularity may suggest that the presence of D allele in the structure of ACE gene is one of the markers of progression of diabetes-induced renal lesion in patients with type I diabetes mellitus One-month captopril therapy in patients with evolving DN (n = l3) causes a statistically significant decrease in MAU. At the same time, there were no significant differences in the group of patients with different allele genotypes of ACE.

I/D-полиморфизм гена АПФ, diabetic nephropathy, genetics of diabetic nephropathy, insertion/deletion polymorphism of angiotensin-converting enzyme gene, angiotensin-converting inhibitors

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