Impact of combined therapy with the ACE inhibitor enalaprii and the thiazide-type agent chlortalidone on the functional status of great arteries in outpatients with arterial hypertension

Thirty patients with grades 1-3 arterial hypertension were examine to evaluate in patients with arterial hypertension the effectiveness and safety of treatment in patients with angiotensin-converting enzyme (ACE) inhibitor enalapril and the thiazide-type diuretic chlortalidone and to study the impact of this therapy on the great arteries. This combined therapy could reduce systolic blood pressure (BP) from 166,9 ± 22,8 to 135,7 ± 14,1 mm Hg, diastolic BP from 101,8 ± 22,8 to 135,7 ± 14,1 mm Hg (p < 0,001). Baseline pulse pressure was 68,9 ± 16,2 mm Hg, alter 12-week therapy, it was 50,5 ± 12,2 mm Hg (p < 0,001). Volumetric sphygmography demonstrated a reduction in arterial rigidity. The rate of pulse wave propagation significantly decreased from 14,8 ± 2,0 to l4,l ± 1,9 m/sec. Symmetrical changes were also observed in the rigidity of vessels, as also evidenced by the data of high-resolution ultrasound. The rigidity p-index reduced by almost 2596 - from 35,5 ± 13,3 to 26,8 ± l6,3; p = 0,02.The reduction in the rigidity of common femoral arteries was confirmed by a rise in their elasticity the compliance coefficient clearly tended to increase. Thus, the use of enarenal and oxodoline improved the function of great arteries just within the first 3 months of therapy.

arterial hypertension, functional status of great arteries, enarenal, oxodoline

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