24-hour blood pressure monitoring and the results of antihypertensive therapy in patients with hypertensive disease in the presence of cervical osteoarthrosis

Abstract

The changes m 24-hour blood pressure (BP) monitoring were studied in 63 patients with grade I hypertension concurrent with cervical osteoarthrosis in the treatment with the angiotensin-converting enzyme (ACE) inhibitor enalapril in combination with hydrochlorothiazide. The degenerative and dystrophic process in the cervical pan of the spine was shown to exert a negative effect on the daily BP profile, by increasing the variability and the morning elevation of BP, to keep antihypertensive agents from producing their adequate effect. The hypertensive patients with die vertebral arterial syndrome respond to therapeutic measures worse, which shows it necessary to apply a differential approach to treating this category of patients.