Docs the genotype of alcohol dehydrogenase-2 affect a cardiovascular responsiveness to acute alcohol load in healthy males?

Objective. To study the specific features of cardiovascular responsiveness to acute alcoholic load in healthy male volunteers in relation to the genotype of alcohol dehydrogenase-2 (ADG2) by 24-hour monitoring of blood pressure (BP) and heart rate (HR) Methods. A study group comprised 32 healthy males (mean age 22.9 years) episodically consuming alcohol without a history of abnormal reactions, arterial hypertension (AH) and taking no antihypertensive agents, who had a level or clinical BP of < 140/<90 mm Hg. The alcohol load was 1.5 g of absolute ethanol per kg hotly weight. The BP measured at the same o'clock on the day of taking a soft drink was regarded as a control level. 24-hour monitoring was made on the day of using alcohol and a soft drink. The genotypes of ADG2 and aldehyde dehydrogenase 2 (AIDG2) were determined by polymerase chain reaction according to the standard protocol. Results. 20 (62.5 %) persons were carriers of the ADG2 - 1/1 genotype; the homozygotes of ADG2 - 2/2 were absent; all the participants had the ALDG2 - 1/1 genotype. The total group showed no differences in the average values of systolic (SBR), diastolic (DBP), mean (Bpmean), and pulse pressures (PP) on the day of taking vodka and a control soft drink during a day, daylight and night hours. The ADG2 - 1/1 group exhibited an insignificant increase in SBP and PP and a significant rise in HR on the day of taking vodka versus the control drink The persons with the AGD2 - 2/1 genotype responded to alcohol use as an insignificant decrease in BP and a less marked increase in HR during daylight hours and a more pronounced rise in HR at night. The same direction of differences in PP values was noted in the period of the maximum alcohol concentration in the expired air. In the period of alcohol elimination. MP and HR after alcohol use did not differ from these parameters after taking the soft drink, but the tendency for higher values in the ADG2 - l/l genotype group persisted, while in the ADG2 - 1/2 genotype group, the higher values of HR only remained. Conclusions. Differences were established in BP and HR reactions to the ingestion of alcohol in heal i by volunteers according to the genotype of ADG2. Elevated BP in persons with the ADG2 - 1/1 genotype suggests that alcohol-induced arterial hypertension may develop in the individuals with this genotype during chronic alcohol intoxication.

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