The effectiveness and safety of Tulip in patients with hyperlipidemia
https://doi.org/10.18705/1607-419X-2005-11-3-201-203
Abstract
The purpose of the study was to evaluate the hypolipidemic effectiveness and safety of use of Tulip, a novel atorvastatin generic agent, registered by LEK, Slovenia, in Russia. Materials and methods. The open prospective uncontrolled study covered in hyperlipidemic patients aged 57,3±1,2 years. Of the 40 patients included into the present study, 19 (47.5 %) achieved the target level of low-density lipoprotein (LDL) cholesterol just by week 4 of therapy when 10 mg of Tulip was used and 7 (17,5 %) patients did by week 8 when 20 mg of the drug was given. As a whole, 65 % of patients achieved the target level of DLD cholesterol in the Tulip group. By treatment week 8, there were35,6; 44,6; 39,8 and 40,9 % decreases in the serum content of total cholesterol, very low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides, respectively. The serum level of LDL cholesterol tended to increase. The pronounced hypolipidemic effect of Tulip was not attended by increases in transaminases (aspartate aminotransferase and alanine aminotranferase) and creatinine phosphokinase. Conclusions. The marked hypolipidemic effect of Tulip, which is comparable with that of the original drug atorvastatin, is unquestionable to he attractable for practical use in Russia due to its inexpensive cost. Tulip has demonstrated to be safe and well tolerated.
About the Authors
O. M. Moiseeva
ФГБУ «Федеральный медицинский исследовательский центр имени В.А. Алмазова» Минздрава России
Russian Federation
Russian Federation
Ye. V. Karelkina
ФГБУ «Федеральный медицинский исследовательский центр имени В.А. Алмазова» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Moiseeva O.M., Karelkina Ye.V. The effectiveness and safety of Tulip in patients with hyperlipidemia. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2005;11(3):201-203. (In Russ.) https://doi.org/10.18705/1607-419X-2005-11-3-201-203
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