Safety, effect anti tolerance of metoprolol in the treatment of elderly and old patients of cardiological profile

Abstract

76 elderly patients with cardiac heart disease (CHD) (31 male and 45 female) were included in the study. Mean age was 81.6 ± 3.4 (from 76 to 89) years. All investigated patients had stable angina pectoris (I-III class). The duration of disease was 8-15 years. The patients were hypertensive (mean arterial pressure 164.5 ± 5.8 / 100 ± 4.3 mm Hg) and had clinical symptoms of heart failure (II class by NYHA). The mental status was evaluated by variety specific tests. The quality of life was assessed by using questionnaire scale SF-36 Health Stains Survey. All subjects were treated by nitrates. ACE-inhibitors and diuretics. Patienis were divided into 2 groups, clinical data and demographies signs of witch, were comparable. 29 patients (1 group) received Metocard 25-100 mg per day. 27 patients were included in control group. Patients of 1 group demonstrated more pronounced increase of distance in test with 6-minutes walking. The depression level after treatment period was significantly reduced in patients of 1 group compare with control group and it's precede level (Camilton scale). Evaluation of quality of life following treatment period shewed statistically significant improvement of number indexes of scale SF-36 Health Status Survey.