Effects of ß-adrenergic blokers on the growth of explantat of cardiac tissue
https://doi.org/10.18705/1607-419X-2006-12-3-248-251
Abstract
The method of organotypical cell culture was used. The long-term cell culture of cardiac embryonic tissue of 10-12-days old chicken was investigated. The effects of ß1-adrenergic blockers (atenolol, metoprolol) and noradrenaline on the growth of explantat cardiac tissue were measured quantitatively. It was found that ß1-adrenergic bloker atenolol in 10-6 M and 10-4 M concentration stimulated growth of cardiac tissue on 23% and 40% correspondently. Atenolol in 10-8 M concentration, contrary, depressed growth of explantat. Metoprolol (10-12 - 10-4 M) inhibited the growth of explantat cardiac tissue. Noradrenaline (10-12 M) stimulated growth of explantat cardiac tissue. However the joint action of noradrenaline (10-12 M) and metoprolol or atenolol did not influence on growth explantat cardiac tissue. These results suggest that cardiac tissue stimulating effect of noradrenaline mediated through activation of ß1-adrenergic receptors.
About the Authors
V. A. Tsyrlin
V.A. Almazov Research Institute of Cardiology
Russian Federation
Russian Federation
E. V. Lopatina
V.A. Almazov Research Institute of Cardiology
Russian Federation
Russian Federation
V. A. Penniyaynen
Pavlov Institute of Physiology, Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Tsyrlin V.A., Lopatina E.V., Penniyaynen V.A. Effects of ß-adrenergic blokers on the growth of explantat of cardiac tissue. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2006;12(3):248-251. (In Russ.) https://doi.org/10.18705/1607-419X-2006-12-3-248-251
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