The Method of apolipoprotein(a) Gene G/A - 772 Polymorphism Detection and the Study of It’s Role in Coronary Heart Disease in intercoronary Stent Placement
https://doi.org/10.18705/1607-419X-2006-12-3-273-278
Abstract
The present study evaluates plasma lipid profile and inflammatory proteins, including lipoprotein(a) [Lp(a)] and apolipoprotein(a) gene single nucleotide polymorphism (SNP) G/А located 772 b.p. upstream transcription start site, in 80 patients undergoing stenting after coronary angioplasty. A novel method of G/А polymorphism detection is described. Our study is the first one to reveal the role of G/А SNP in regulation of plasma Lp(a) levels. We describe an association of LDL and Lp(a) systems limited only to the group of patients with restenosis after coronary stenting. Plasma apolipoprotein Al level increase after stenting was characteristic of better prognosis. The acute phase proteins are studied in association with clinical and angiographic presentation of coronary heart disease. Our data is relevant both to fundamental studies of atherosclerosis and to clinical practice, and may be used in assessment of coronary heart disease clinical course and selection of treatment options.
About the Authors
J. V. Skorobogatova
V.A. Almazov Russian Reseach Institute for Cardiology
Russian Federation
Russian Federation
A. A. Soshnev
St-Petersburg State University
Russian Federation
Russian Federation
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Review
For citations:
Skorobogatova J.V., Soshnev A.A. The Method of apolipoprotein(a) Gene G/A - 772 Polymorphism Detection and the Study of It’s Role in Coronary Heart Disease in intercoronary Stent Placement. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2006;12(3):273-278. (In Russ.) https://doi.org/10.18705/1607-419X-2006-12-3-273-278
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