HYPOTENSIVE DRUGS EFFECT AND LIVER MONOOXIGENASE FUNCTION IN ARTERIAL HYPERTENSION PATIENTS AFTER ADRENAL HYPERFUNCTION CORRECTION
https://doi.org/10.18705/1607-419X-2007-13-4-262-265
Abstract
Hypotensive drug tolerance and liver monooxygenase activity were investigated in 24 refractory arterial hypertension patients before and after surgical suppression of adrenal hyperfunction. Liver monooxygenase activity was studied using antipyrine test. It was found that hypotensive drug tolerance was decreased after one and two side operations on adrenal glands. In parallels halftime of antipyrine elimination was shown to be prolonged by 88.5% in 3 months - 3 years after suppression of adrenal hyperfunction. Our findings suggest that the hypotensive drug tolerance diminution may be the consequence of liver monooxygenase activity reduction. This assumption is in accordance with well known the hypotensive drug metabolism by microsomal liver monooxygenases
About the Authors
A. S. Kogan
Scientific Center of Reconstructive Surgery SB RAMS, Irkutsk
Russian Federation
Russian Federation
V. V. Lomivorotov
Research Institute of Circulation Pathology, Novosobirsk
Russian Federation
Russian Federation
M. N. Deryagin
Research Institute of Circulation Pathology, Novosobirsk
Russian Federation
Russian Federation
M. A. Novikov
Research Institute of Circulation Pathology, Novosobirsk
Russian Federation
Russian Federation
V. A. Nepomnyashchikh
Research Institute of Circulation Pathology, Novosobirsk
Russian Federation
Russian Federation
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Review
For citations:
Kogan A.S., Lomivorotov V.V., Deryagin M.N., Novikov M.A., Nepomnyashchikh V.A. HYPOTENSIVE DRUGS EFFECT AND LIVER MONOOXIGENASE FUNCTION IN ARTERIAL HYPERTENSION PATIENTS AFTER ADRENAL HYPERFUNCTION CORRECTION. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2007;13(4):262-265. (In Russ.) https://doi.org/10.18705/1607-419X-2007-13-4-262-265
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