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Современные представления о гипергомоцистеинемии как факторериска сердечно-сосудистых заболеваний

https://doi.org/10.18705/1607-419X-2008-14-2-110-115

Полный текст:

Аннотация

Резюме
Тяжелая гипергомоцистеинемия, вызванная редкими наследственными нарушениями метаболизма гомоцис-теина, приводит к многократному увеличению риска атеротромбоза. Даже частичная коррекция уровня гомоцис-теина у пациентов с тяжелой гипергомоцистеинемией позволяет существенно уменьшить частоту возникновения сердечно-сосудистых осложнений. Умеренная гипергомоцистеинемия широко распространена в популяции и коррелирует с повышенным риском развития заболеваний сердечно-сосудистой системы. В экспериментальных моделях умеренная гипергомоцистеинемия вызывает эндотелиальную дисфункцию, предрасполагает к тромбозу и ускоряет развитие атеросклероза. На основании эпидемиологических и экспериментальных данных была выдвинута гипотеза, что коррекция умеренной гипергомоцистеинемии может существенно уменьшить риск развития заболеваний сердечно-сосудистой системы. Вопреки ожиданиям, серия крупных клинических исследований показала, что снижение уровня гомоцистеина при умеренной гипергомоцистеинемии не влияет на риск развития сердечнососудистых заболеваний. В данной статье обсуждаются современные представления о гипергомоцистеинемии как факторе риска развития заболеваний сердечно-сосудистой системы в свете отрицательных результатов клинических исследований по коррекции уровня гомоцистеина при умеренной гипергомоцистеинемии.

Об авторах

Р. Родионов
Медицинский Факультет Университета Айовы
Россия


С. Лентц
Медицинский Факультет Университета Айовы
Россия


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Для цитирования:


Родионов Р., Лентц С. Современные представления о гипергомоцистеинемии как факторериска сердечно-сосудистых заболеваний . Артериальная гипертензия. 2008;14(2):110-115. https://doi.org/10.18705/1607-419X-2008-14-2-110-115

For citation:


Rodionov R., Lentz S. Hyperhomocystcinemia as a cardiovascular risk factor. Current concepts . "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2008;14(2):110-115. (In Russ.) https://doi.org/10.18705/1607-419X-2008-14-2-110-115

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