Polymorphisms of renin-angiotensin system genes and endothelial dysfunction in young males with a history of myocardial infarction
https://doi.org/10.18705/1607-419X-2008-14-3-239-244
Abstract
We studied relationship between renin-angiotensin system (RAS) gene polymorphisms and parameters of endothelial function in males with history of myocardial infarction in young age. We found endothelial dysfunction in these patients. There were no correlations between certain polymorphic genes and risk of myocardial infarction. At the same time, insertion/deletion polymorphism of the angiotensin-converting enzyme gene was associated with more prominent endothelial dysfunction in males with history of myocardial infarction in young age. These data may confirm influence of RAS gene polymorphism on the endothelial dysfunction.
About the Authors
O. Bekovitch
Pavlov State Medical University, St.Petersburg
Russian Federation
Russian Federation
E. Bazhenova
Pavlov State Medical University, St.Petersburg
Russian Federation
Russian Federation
N. Vakhrameeva
Pavlov State Medical University, St.Petersburg
Russian Federation
Russian Federation
E. V. Volkova
Pavlov State Medical University, St.Petersburg
Russian Federation
Russian Federation
V. Larionova
Pavlov State Medical University, St.Petersburg
Russian Federation
Russian Federation
E. V. Shlyakhto
Pavlov State Medical University, St.Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Bekovitch O., Bazhenova E., Vakhrameeva N., Volkova E.V., Larionova V., Shlyakhto E.V. Polymorphisms of renin-angiotensin system genes and endothelial dysfunction in young males with a history of myocardial infarction . "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2008;14(3):239-244. (In Russ.) https://doi.org/10.18705/1607-419X-2008-14-3-239-244
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