Pharmacological regulation of the cardiomyocyte growth in tissue culture
https://doi.org/10.18705/1607-419X-2008-14-4-369-372
Abstract
Norepinephrine, blockers of beta-adrenoreceptors, angiotensin-converting enzyme inhibitors and angiotensin I receptor blocker were investigated in organotypic tissue culture of cardiomyocytes of 10-12-day-old chicken embryos and newborn rat heart in a wide range of concentrations. The data obtained show that low concentration of norepinephrine led to the cardiomyocyte growth control. The application of beta-adrenoblockers metoprolol and atenolol prevented stimulating effect of norepinephrine. Zofenopril inhibited the growth of cardiomyocytes but enalapril had no effect on this process. The effect of angiotensin I receptor blocker depended on concentration - low concentrations resulted in activation of cardiomyocyte growth; and high concentrations led to the decrease of their growth.
About the Authors
E. V. Lopatina
V. A. Almazov Federal Heart, Blood and Endocrinology Centre
Russian Federation
Russian Federation
L. A. Gevorkova
V. A. Almazov Federal Heart, Blood and Endocrinology Centre
Russian Federation
Russian Federation
E. V. Kuleshova
V. A. Almazov Federal Heart, Blood and Endocrinology Centre
Russian Federation
Russian Federation
V. A. Penniyaynen
Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia
Russian Federation
Russian Federation
V. A. Tsyrlin
V. A. Almazov Federal Heart, Blood and Endocrinology Centre
Russian Federation
Russian Federation
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Review
For citations:
Lopatina E.V., Gevorkova L.A., Kuleshova E.V., Penniyaynen V.A., Tsyrlin V.A. Pharmacological regulation of the cardiomyocyte growth in tissue culture. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2008;14(4):369-372. (In Russ.) https://doi.org/10.18705/1607-419X-2008-14-4-369-372
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