BAROREFLEX AND ADAPTATION OF VISCERAL SYSTEMS IN RENOVASCULAR HYPERTENSION
https://doi.org/10.18705/1607-419X-2013-19-1-32-37
Abstract
Objective. To test the hypothesis, that the arterial baroreceptor refl ex plays the key role for the phenomenon of visceral systems adaptation for long-term afferent drive.
Design and methods. In Wistar rats the model of the «two kidneys, one clip» vasorenal hypertension was carried out. The sino-aortic denervation was performed in one group — before the left renal artery clipping, in the other group — 8 weeks after the left renal artery clipping.
Results. The renal artery clipping led to the increase of blood pressure only in 17 % of animals with intact sino-carotid-aortic mechanoreceptor zones. The absence of hypertension in these animals might be due to the cardiovascular adaptation phenomenon to prolonged afferent action from ischemic kidney. Denervation of mechanoreceptor zones before the clipping of the renal artery contributes to the development of hypertension in 100 %. However, the denervation of sino-carotid and aortic zones performed 8 weeks after the renal artery clipping in rats without hypertension, does not affect blood pressure level.
Conclusion. We suggest, that the absence of hypertension after renal artery clipping is due to the adaptation of the circulatory system to a long-term afferentation from the kidney, and the denervation of large vessels mechanoreceptor zones does not alter this process. At the same time, the damage of the arterial baroreceptor refl ex before renal artery clipping interferes in the visceral systems adaptation to afferent action and contributes to the arterial hypertension development.
About the Authors
V. A. Tsyrlin
Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg;
Pavlov St Petersburg State Medical University, St Petersburg, Russia
Russian Federation
Russian Federation
N. V. Kuzmenko
Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg;
Pavlov St Petersburg State Medical University, St Petersburg, Russia
Russian Federation
Russian Federation
Corresponding author: Almazov Federal Heart, Blood and Endocrinology Centre, 2 Akkuratov st., St Petersburg, Russia, 197341. E-mail: kuzmenko@niiekf.ru (Natalia V. Kuzmenko, PhD of Biology Sciences, Senior Researcher at the Department of Experimental Physiology and Pharmacology at Almazov Federal Heart, Blood and Endocrinology Centre, and at the Laboratory of Circulation Biophysics at Pavlov St Petersburg State Medical University).
M. G. Pliss
Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg;
Pavlov St Petersburg State Medical University, St Petersburg, Russia
Russian Federation
Russian Federation
N. S. Rubanova
Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg;
Pavlov St Petersburg State Medical University, St Petersburg, Russia
Russian Federation
Russian Federation
References
1. Weinstock M., Gorodetsky E., Kalman R. Renal denervation prevents sodium retention and hypertension in salt-sensitive rabbits with genetic barorefl ex impairment // Clin. Sci. — 1996. — Vol. 90, № 4. — P. 287–293.
2. Kline R.L., Kelton P.M., Mercer P.F. Effect of renal denervation on the development of hypertension in spontaneously hypertensive rats // Can. J. Physiol. Pharmacol. — 1978. — Vol. 56, № 5. — P. 818–822.
3. Kline R.L., Denton K.M., Anderson W.P. Effect of renal denervation on the development of cellophane-wrap hypertension in rabbits // Clin. Exp. Hypertens. — 1986. — Vol. 8, № 8. — P. 1327–1342.
4. Vari R.C., Freeman R.H., Davis J.O. et al. Role of renal nerves in rats with low-sodium, one-kidney hypertension // Am. J. Physiol. — 1986. — Vol. 250, № 2, Pt. 2. — P. H189-H194.
5. Norman R.A., Murphy W.R., Dzielak D.J. et al. Role of the renal nerves in one-kidney, one clip hypertension in rats // Hypertension. — 1984. — Vol. 6, № 5. — P. 622–626.
6. Емельянов И.В., Звартау Н.Э., Конради А.О. и др. Резистентная артериальная гипертензия / Под ред. Е.В. Шляхто. — СПб., 2012. — 117 с. / Yemelyanov I.V., Zvartau N.E., Konradi A.O. et al. Resistant arterial hypertension / Ed. by E.V. Shlyakhto. — St Petersburg, 2012. — 117 p. [Russian].
7. Wyss J.M., Donovan M.K. A direct projection from the kidney to the brainstem // Brain Res. — 1984. — Vol. 298, № 1. —P. 130–134.
8. Wyss J.M., Aboukarsh N., Oparil S. Sensory denervations of the kidney attenuates renovascular hypertension in the rat // Am. J. Physiol. — 1986. — Vol. 250, № 1, Pt. 2. — P. H82-H86.
9. Winternitz S.R., Katholi R.E., Oparil S. Decreased in hypothalamic norepinephrine content following renal denervation in the one-kidney, one clip Goldblatt hypertensive rat // Hypertension. — 1982. — Vol. 4, № 3. — P. 369–373.
10. Osborn J.W. Hypothesis: set-points and long-term control of arterial pressure. A theoretical argument for a long-term arterial pressure control system in the brain rather than the kidney // Clin. Exper. Pharmacol. Physiol. — 2005. — Vol. 32. — P. 384–393.
11. Черниговский В.Н. Часть 5. Привыкание (адаптация) и поведение висцеральных систем. Избранные труды. — СПб.:Наука, 2007. — С. 431–460. / Chernigovsky V.N. Part 5. Addictive (adaptation) and visceral behavior of visceral systems. Selected works. — St Petersburg: Science, 2007. — P. 431–460 [Russian].
12. Kopp U.C., Buckley-Bleiler R.L. Impaired renorenal reflexes in two-kidney, one clip hypertensive rats // Hypertension. — 1989. — Vol. 14, № 4. — P. 445–452.
13. Wagner C., Hinder M., Krämer B.K. et al. Role of renal nerves in the stimulation of the renin system by reduced renal arterial pressure // Hypertension. — 1999. — Vol. 34, № 5. — P. 1101–1105.
14. Abboud F.M. The sympathetic system in hypertension. State-of-the-art review // Hypertension. — 1982. — Vol. 4, suppl II. — P. II–208–II–225.
15. Dargie H.J., Franklin S.S., Reid J.L. Plasma noradrenaline concentrations in experimental renovascular hypertension in the rat // Clin. Sci. Mol. Med. — 1977. — Vol. 52, № 5. — P. 477–482.
16. Robertson J.I., Morton J.J., Tillman D.M. et al. The pathophysiology of renovascular hypertension // J. Hypertens. — 1986. — Vol. 4, № 4. — P. S95-S103.
17. Кузьменко Н.В., Плисс М.Г., Рубанова Н.С. Cимпатическая активность и вариабельность сердечного ритма при экспериментальной реноваскулярной гипертензии у крыс с интактными и денервированными барорецепторными зонами // Бюлл. ФЦСКЭ им. В.А. Алмазова. — 2011. — № 3. — С. 31–37. / Kuzmenko N.V., Pliss M.G., Rubanova N.S. Sympathetic activity and heat rate variability during experimental renovascular hypertension in intact and sino-aortic denervated rats // Bulletin of the Almazov Federal Heart, Blood and Endocrinology Centre [Bulleten FCSKE imeni V.A. Almazova]. — 2011. — №. 3. — P. 31–38 [Russian].
18. Цырлин В.А., Кузьменко Н.В., Плисс М. и др. Соматосимпатический рефлекс у крыс с разными моделями артериальной гипертензии // Росс. физиол. журн. — 2011. — Т. 97, № 5. — С. 498–508. / Tsyrlin V.A., Kuzmenko N.V., Pliss M.G. et al. Somatosympathetic refl ex in rats with various models of arterial hypertension // Russian Physiology Journal [Rossiyskiy Fisiologicheskiy Zhurnal]. — 2011. — Vol. 97, №. 5. — P. 498–508 [Russian].
19. Stella A., Golin R., Genovesi S., Zanchetti A. Renal refl exes in the regulation of blood pressure and sodium excretion // Can. J. Physiol. Pharmacol. — 1987. — Vol. 65, № 8. — P. 1536–1539.
20. Цырлин В.А., Кузьменко Н.В., Плисс М.Г. Участие артериального барорецепторного рефлекса в долговременной регуляции артериального давления // Артериальная гипертензия. — 2009. — Т. 15, № 6. — С. 679–682. / Tsyrlin V.A., Kuzmenko N.V., Pliss M.G. Baroreceptor refl ex role in blood pressure long-term regulation // Arterial Hypertension [Arterialnaya Gipertenziya]. — 2009. — Vol. 15, №. 6. — P. 679–682 [Russian].
21. Шляхто Е.В., Плисс М.Г., Цырлин В.А. Барорецепторный рефлекс и долговременная регуляция артериального давления. — СПб., 2011. — 153 с. / Shlyakhto E.V., Tsyrlin V.A., Pliss M.G. Baroreceptor refl ex and the long-term regulation of blood pressure. — St Petersburg, 2011. — 153 p. [Russian].
22. Шляхто Е.В., Конради А.О., Цырлин В.А. Вегетативная нервная система и артериальная гипертензия. — СПб.: ООО «Медицинское издательство», 2008. — 312 с. / Shlyakhto E.V., Konradi A.O., Tsyrlin V.A. The autonomic nervous system and arterial hypertension. — St Petersburg: OOO «Medical publishing house», 2008. — 312 p. [Russian].
23. Rodrigues M.C., Campagnole-Santos M.J., Machado R.P. et al. Evidence for a role of AT (2) receptors at the CVLM in the cardiovascular changes induced by low-intensity physical activity in renovascular hypertensive rats // Peptides. — 2007. — Vol. 28, № 7. — P. 1375–1382.
Review
For citations:
Tsyrlin V.A., Kuzmenko N.V., Pliss M.G., Rubanova N.S. BAROREFLEX AND ADAPTATION OF VISCERAL SYSTEMS IN RENOVASCULAR HYPERTENSION. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2013;19(1):32-37. (In Russ.) https://doi.org/10.18705/1607-419X-2013-19-1-32-37
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