VITAMIN D AND COMPONENTS OF METABOLIC SYNDROME IN WOMEN OF REPRODUCTIVE AGE WITH DIFFERENT GENOTYPES OF VITAMIN D RECEPTOR GENE APAI POLYMORPHISM

Objective. Recent studies suggest high prevalence of vitamin D deficiency and its association with metabolic disturbances. However, the available data regarding the relationship between vitamin D level, vitamin D receptor gene polymorphisms and components of metabolic syndrome seem to be contradictory. We examined the interrelations between serum 25(OH)D and vitamin D receptor gene ApaI polymorphism with the parameters of metabolic syndrome.

 Results of the study showed that 83,4 % of the study population had vitamin D deficiency/insuffiiency and vitamin D level inversely correlated with body weight. Correlation analysis showed that women with vitamin D deficiency had higher risk of obesity and decreased high-density lipoproteins level than women with normal 25(OH)D level. Moreover, women with vitamin D deficiency showed a tendency for having impaired glucose metabolism. We did not fisignificant associations between vitamin D level and blood pressure and metabolic syndrome. AA, Aa and aa genotypes prevalence and A/a allele incidence of ApaI vitamin D receptor gene polymorphism did not differ significantly in study population and control group. A allele carriers had higher total cholesterol and low-density lipoproteins levels than other genotypes carriers.

Conclusion. Our results showed that vitamin D deficiency and A allele of vitamin D receptor gene ApaI polymorphism might possibly be an unconventional risk factor for metabolic diseases

vitamin D insufficiency/deficiency, obesity type 2 diabetes mellites, dyslipidemia, vitamin D receptor gene polymorphism, metabolic syndrome

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