THE IMPACT OF ANTI B-CELL THERAPY ON ARTERIAL STIFFNESS IN SYSTEMIC SCLERODERMA
https://doi.org/10.18705/1607-419X-2013-19-3-212-220
Abstract
Background. Arterial wall stiffness is an independent predictor of cardiovascular mortality in different patient populations. Currently, there are several studies that show an increase of arterial wall stiffness in systemic sclerosis (SSc). The effect of immunosuppressive therapy on vascular wall stiffness in SSc patients is not investigated. The authors of this paper attempted to study the effect of rituximab and cyclophosphamide combination therapy on vascular stiffness in 5 patients with diffuse form of SSc.
Design and methods. We assessed arterial stiffness in 5 patients with diffuse form of SSc before and after 6 months after combined immunosuppressive therapy.
Conclusion. The parameters of arterial stiffness decreased in all patients with the moderate effect of the therapy.
About the Authors
A. L. Maslyanskiy
Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg
Russian Federation
Russian Federation
Corresponding author: Almazov Federal Heart, Blood and Endocrinology Centre, 2 Akkuratov st., St Petersburg, Russia, 197341. E-mail: esc_4@mail.ru (Alexei L. Maslyanskiy, Senior Researcher in Scientifi c Laboratory of Rheumatology at Almazov Federal Heart, Blood and Endocrinology Centre).
E. P. Kolesovа
Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg
Russian Federation
Russian Federation
I. N. Penin
Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg
Russian Federation
Russian Federation
M. D. Cheshuina
Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg
Russian Federation
Russian Federation
S. V. Lapin
Pavlov St Petersburg State Medical University, St Petersburg
Russian Federation
Russian Federation
A. O. Konradi
Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Maslyanskiy A.L., Kolesovа E.P., Penin I.N., Cheshuina M.D., Lapin S.V., Konradi A.O. THE IMPACT OF ANTI B-CELL THERAPY ON ARTERIAL STIFFNESS IN SYSTEMIC SCLERODERMA. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2013;19(3):212-220. (In Russ.) https://doi.org/10.18705/1607-419X-2013-19-3-212-220
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