Leptin levels and A19G leptin gene polymorphisms in patients with abdominal obesity
https://doi.org/10.18705/1607-419X-2009-15-4-440-444
Abstract
Study objective was to evaluate leptin levels in patients with abdominal obesity - carriers of different genotypes of leptin gene. Material and methods: 472 patients aged 30-55 years with abdominal obesity were examined. Leptin level was determined by ELISA, A19G leptin gene polymorphism was evaluated by polymerase chain reaction. Results and conclusion. High leptin level is seen in patients with abdominal obesity (46,5±1,7 ng\ml vs 24,4±3,56 ng/ml in healthy subjects, p=0,0001). Leptin levels were higher in women than in men (51,7±1,8 vs 29,7±3,1 ng/ml, p<0,0001). Leptin levels in patients with abdominal obesity did not vary depending on different genotypes of leptin gene. In patients with abdominal obesity GG genotype was seen more often that in general population (p=0.04).
About the Authors
O. D. Belyaeva
St Petersburg State Medical University;
St Petersburg State Pediatric Academy
Russian Federation
St Petersburg
Russian Federation
St Petersburg
E. A. Bazhenova
St Petersburg State Medical University;
St Petersburg State Pediatric Academy
Russian Federation
St Petersburg
Russian Federation
St Petersburg
A. V. Berezina
St Petersburg State Medical University;
St Petersburg State Pediatric Academy
Russian Federation
St Petersburg
Russian Federation
St Petersburg
O. O. Bolshakova
St Petersburg State Medical University;
St Petersburg State Pediatric Academy
Russian Federation
St Petersburg
Russian Federation
St Petersburg
E. A. Chubenko
St Petersburg State Medical University;
St Petersburg State Pediatric Academy
Russian Federation
St Petersburg
Russian Federation
St Petersburg
A. E. Garanina
St Petersburg State Medical University;
St Petersburg State Pediatric Academy
Russian Federation
St Petersburg
Russian Federation
St Petersburg
V. B. Timoshin
St Petersburg State Medical University;
St Petersburg State Pediatric Academy
Russian Federation
St Petersburg
Russian Federation
St Petersburg
V. I. Larionova
St Petersburg State Medical University;
St Petersburg State Pediatric Academy
Russian Federation
St Petersburg
Russian Federation
St Petersburg
E. I. Baranova
St Petersburg State Medical University;
St Petersburg State Pediatric Academy
Russian Federation
St Petersburg
Russian Federation
St Petersburg
O. A. Berkovich
St Petersburg State Medical University;
St Petersburg State Pediatric Academy
St Petersburg
St Petersburg
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Review
For citations:
Belyaeva O.D., Bazhenova E.A., Berezina A.V., Bolshakova O.O., Chubenko E.A., Garanina A.E., Timoshin V.B., Larionova V.I., Baranova E.I., Berkovich O.A. Leptin levels and A19G leptin gene polymorphisms in patients with abdominal obesity. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2009;15(4):440-444. (In Russ.) https://doi.org/10.18705/1607-419X-2009-15-4-440-444
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