Polymorphisms of сlot formation genes and their role in myocardial infarction
https://doi.org/10.18705/1607-419X-2009-15-4-466-469
Abstract
Gene polymorphisms of α-Fibrinogen Thr312Ala, Factor XIII Val34Leu, PAI-1 4/5G и Factor V Leiden, responsible for activity and structure of fibrinogen and plasminogen, are studied as predisposing genetic factors to myocardial infarction. Deoxyribonucleic acid (DNA) extracted from dried bloodspots was used as a matrix for PCR analysis. The new improved molecular genetic methods were elaborated and used. Genotype distribution of Thr312Ala and Val34Leu polymorphisms alleles in patients with myocardial infarction and control subjects was significantly different. 2,5-fold increase of allele 34Leu homozygote frequency in patients with myocardial infarction as compared to control group may indicate an increased risk of the disease in people with LL genotype. It was shown that 4G/4G genotype of PAI-1 gene can predispose to myocardial infarction, and 5G/5G one can be protective. 2,3-fold increase of Factor V Leiden mutation frequency in studied group as compared to control subjects supports the hypothesis that this mutation is also a risk factor for myocardial infarction.
About the Authors
A. L. Gonchar
Institute of Genetics and Cytology of Belarus National Academy of Sciences
Belarus
Minsk
Belarus
Minsk
I. B. Mosse
Institute of Genetics and Cytology of Belarus National Academy of Sciences
Belarus
Minsk
Belarus
Minsk
A. A. Ivanov
Institute of Genetics and Cytology of Belarus National Academy of Sciences
Belarus
Minsk
Belarus
Minsk
K. A. Mosse
Institute of Genetics and Cytology of Belarus National Academy of Sciences
Belarus
Minsk
Belarus
Minsk
N. I. Mosse
Institute of Genetics and Cytology of Belarus National Academy of Sciences
Belarus
Minsk
Belarus
Minsk
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Review
For citations:
Gonchar A.L., Mosse I.B., Ivanov A.A., Mosse K.A., Mosse N.I. Polymorphisms of сlot formation genes and their role in myocardial infarction. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2009;15(4):466-469. (In Russ.) https://doi.org/10.18705/1607-419X-2009-15-4-466-469
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