Enalapril role in differentiation of low-renin hypertension
https://doi.org/10.18705/1607-419X-2009-15-4-507-511
Abstract
Objective. The paper addresses enelapril effects and its role in low-renin hypertension (LRH). Design and methods. 190 patients (mean age 54 ± 10 years, mean systolic blood pressure (BP) was 199,6 ± 6,6 mmHg, diastolic BP - 111,4 ± 5,4 mmHg) with LRH were included: 144 of them with low-renin primary hypertension (LRPH), 32 with primary idiopathic hyperaldocteronism (PIHA), and 14 patients had both LRPH and PIHA symptoms. Plasma rennin activity (PRA) and plasma aldosterone (PA) were estimated by radioimmune method at baseline and after 4-week treatment by 20 mg enalapril. PRA was rated as normal if ranged 1,0-3,0 ng/ml/h, PA - 0,18-0,83 nmol/l (5-23 ng/dl or 50-230 pg/ml). Normal PA/PRA ratio was 5-23. Conclusion. Angiotensin-dependent hypertension, rennin stimulation and changes in rennin-angiotensin-aldosterone system activity can be assessed by test with 20 mg/day enalapril intake, that enables differentiating different hypertension forms.
About the Authors
Sh. V. Akhadov
Clinical Hospital № 81;
Clinical Hospital № 154
Russian Federation
Moscow
Russian Federation
Moscow
G. R. Ruzbanova
Clinical Hospital № 81;
Clinical Hospital № 154
Russian Federation
Moscow
Russian Federation
Moscow
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Review
For citations:
Akhadov Sh.V., Ruzbanova G.R. Enalapril role in differentiation of low-renin hypertension. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2009;15(4):507-511. (In Russ.) https://doi.org/10.18705/1607-419X-2009-15-4-507-511
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