Hypertension in pregnant females with the risk of thrombogenicity: clinical forms, target organs damage and hemostatic parameters

Abstract

Objective. To study the influence of different forms of hypertension on course, target organs and hemostatic parameters in pregnant women with thrombogenic risk factors in a cohort study with mixed cohort (retrospective and prospective). Design and methods. 2 groups were formed: main group included pregnant hypertensive women (n = 200), and comparison group - normotensive pregnant women (n = 300). Results. Hypertensive women were oftener overweight (41 % vs. 6,7 %, p < 0,001; RR = 9,8, 95 % CI 5,9-15,9), compromised heredity upon hypertension (52 % vs. 5,3 %, p < 0,001: RR = 6,2, 95 % CI 3,9-9,7). Left ventricle hypertrophy and microalbuminuria were found in 21 % hypertensive women (in retrospective cohort). Women with chronic hypertension showed higher frequency of thrombogenic haemostatic shifts since the first trimester, women with gestosis - since the second trimester with the highest expression in the third trimester of pregnancy. The pregnancy hypertensive women was characterized by higher frequency of early gestosis (34,5 % vs. 22,3 %, p = 0,003; RR = 1,5, 95 %CI 1,2-2,1), chronic placental insufficiency (26,5 % vs. 12 %, p < 0,001; RR = 2,2, 95 % CI 1,5-3,2) and premature delivery (22,5 % vs. 8,3 %, p < 0,001; RR = 2,5, 95 % C1 1,5-4,1) in comparison with women without hypertension.