Molecular mechanismsof insulin resistance
https://doi.org/10.18705/1607-419X-2010--5-
Abstract
The main objective of the article was to describe the molecular mechanisms of insulin resistance. Insulin resistance is characterized by disturbance of the response on the action of external and internal insulin. Insulin resistance causes increase of the insulin level in the blood plasma, as compared to the level of insulin that corresponds to the actual glucose level. The mechanism of insulin resistance is not clear enough. Disorders resulting in the insulin resistance may occur at following levels of the metabolic pathway of insulin: pre-receptor (abnormal insulin), receptor, glucose transport level (decrease the quantity of GLUT4), post-receptor (disturbance of signal transmission).
About the Authors
O. M. Drapkina
I.M. Sechenov First Moscow State Medical University, Moscow
Russian Federation
Russian Federation
J. O. Shifrina
I.M. Sechenov First Moscow State Medical University, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Drapkina O.M., Shifrina J.O. Molecular mechanismsof insulin resistance. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2010;16(5):436-440. (In Russ.) https://doi.org/10.18705/1607-419X-2010--5-
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