Локальныежировые депо как фактор риска сердечно-сосудистых заболеваний
Аннотация
Ожирение ассоциируется с риском развития сердечно-сосудистой патологии. Одним из механизмов, ведущих к сердечно-сосудистым осложнениям является гормональная активность локальных жировых депо. Белая жировая ткань, расположенная в эпикардиальной, висцеральной, паранефральной и периваскулярной областях, оказывает не только локальное механическое воздействие на рядом расположенные органы, но и системное действие через биологически активные вещества. Проатерогенные и провоспалительные хемокины и цитокины вызывают хроническое воспаление сосудистой стенки, пролиферацию и миграцию гладкомышечных клеток, трансформацию моноцитов в макрофаги, что ведет к дисфункции эндотелия, формированию атеросклеротической бляшки и прогрессированию атеросклероза.
Об авторах
Г. А. Чумакова
Алтайский государственный медицинский университет
Россия
Россия
Н. Г. Веселовская
Научно-исследовательский институт Комплексных проблем сердечно-сосудистых заболеваний Сибирского отделения РАМН
Россия
Россия
А. А. Козаренко
Научно-исследовательский институт Комплексных проблем сердечно-сосудистых заболеваний Сибирского отделения РАМН
Россия
Россия
Л. С. Барбараш
Алтайский краевой кардиологический диспансер
Россия
Россия
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Рецензия
Для цитирования:
Чумакова Г.А., Веселовская Н.Г., Козаренко А.А., Барбараш Л.С. Локальныежировые депо как фактор риска сердечно-сосудистых заболеваний. Артериальная гипертензия. 2010;16(5):441-448. https://doi.org/10.18705/1607-419X-2010--5-
For citation:
Chumakova G.A., Veselovskaya N.G., Kоzarenko A.A., Barbarash L.S. Local fat depots asa cardiovascular risk factor. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2010;16(5):441-448. (In Russ.) https://doi.org/10.18705/1607-419X-2010--5-
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