Thyroid function in patients withmetabolic syndrome

Objective. Thyroid disease is associated with atherosclerosis and cardiovascular disease. Little is known about the relationship between insulin resistance and thyroid function. The study addresses the relationship between thyroid function, body mass index (BMI) and homeostasis model assessment index for insulin resistance (HOMA-IR) in patients with heart ischemic disease. Design and methods. 73 patients were included in our study. Assessed parameters included age, gender and BMI. Fasting blood samples were taken for measuring of thyrotrophic hormone (TSH) level, glucose and insulin concentration. HOMA-IR was calculated as fasting insulin (mU/l) times fasting glucose (mmol/l) divided by 22,5. Results. TSH level was higher in patients with obesity (3,05±1,14 IU/l) and overweight (2,73 ± 0,26 IU/I) than in normal weight subjects, IR was the highest in the obese patients (4,67 ± 1,12). HOMA-IR was statistically lower in group I and II: 1,30 ± 0,26 and 1,52 ± 0,74 respectively (p < 0,002 and 0,05). Conclusion. We can propose that thyroid hormones may take part in mechanisms of peripheral insulin resistance.

thyroid function, metabolic syndrome, peripheral insulin resistance

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