Diagnostic significance of the matrix metalloproteinases 9 activity (gelatinase B) in acute coronary syndrome
https://doi.org/10.18705/1607-419X-2010--6-
Abstract
Objective. To study the diagnostic and prognostic value of matrix metalloproteinase 9 (MMP-9) proteolysis system and its relationship to universal inhibitor alpha-2-macroglobulin (A2-MG) in serum of patients with acute coronary syndrome (ACS). Design and methods. 188 patients were included in the study of the MMP-9 activity and A2-MG level. Results and conclusions. The maximum increase in MMP-9 was observed in patients with myocardial infarction (MI) compared to those with unstable angina (UA) and controls. Negative correlation between MMP-9 and A2-MG levels was found in patients with IM, indicating the enhanced proteolysis. Significant reduction of A2-MG serum level in patients with MI contributes to local inflammation in atherosclerotic plaque (AP) with its subsequent weakening, destabilization and rupture.
References
1. Оганов Р.Г. Факторы риска и профилактика сердечно-сосудистых заболеваний // Журн. медицина. - 2003. - № 2. - С. 10-15.
2.
3. Диагностика и лечение артериальной гипертензии. Рекомендации Российского медицинского общества по артериальной гипертонии и Всероссийского научного общества кардиологов // Кардиоваск. терапия и профилактика. - 2008. - № 7, прил. 2. - С. 6-32.
4.
5. Nagase H., Okada Y. Proteinases and matrix degradation // In: Textbook of rheumatology / Ed. by W.N. Kelley, E.D. Harris, S. Ruddy, C.B. Sledge, Philadelphia: W.B. Saunders, 1997. - P. 323-341.
6.
7. Tchetverikov I., Lard L.R., DeGroot J. Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint damage progression in early rheumatoid arthritis //Ann. Rheum. Dis. - 2003. - Vol. 62, № 11. - P. 1094-1099.
8.
9. McKeown S., Richter A.G., O'Kane C. et al. MMP expression and abnormal lung permeability are important determinants of outcome in IPF // Eur. Respir. J. - 2009. - Vol. 33, № 1. - P. 77-84.
10.
11. Nishikaku A.S., Ribeiro L.C., Molina R.F. et al. Matrix metalloproteinases with gelatinolytic activity induced by Paracoccidioides brasiliensis infection // Int. J. Exp. Pathol. - 2009. - Vol. 90, № 5. - P. 527-537.
12.
13. Task Force on the management of acute coronary syndromes of the European Society of Cardiology. Management of acute coronary syndromes in patients presenting without persistent ST-segment elevation // Eur. Heart. J. - 2002. - Vol. 23, № 23. - Р. 1809-1840.
14.
15. ACC/AHA Guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients with Unstable Angina) // J. Am. Coll. Cardiol. - 2000. - Vol. 36, № 3. - P. 970-1062.
16.
17. Kai H., Ikeda H., Yasukawa H. et al. Peripheral blood levels of matrix metalloproteinase 2 and 9 are elevated in patients with acute coronary syndromes // J. Am. Coll. Cardiol. - 1998. - Vol. 32, № 2. - P. 368-372.
18.
19. Inokubo Y ., Hanada H ., Ishizaka H et al. Plasma levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 are increased in the coronary circulation in patients with acute coronary syndrome // Am. Heart. J.- 2001. - Vol. 141, № 2. - P. 211-217.
20.
21. Kalela A., Koivu T.A., Sisto T. et al. Serum matrix metalloproteinase-9 concentrationin angiographically assessed coronary artery disease // Scand. J. Clin. Lab. Invest. - 2002. - Vol. 62, № 5. - P. 337-342.
22.
23. Nagase H., Barrett A. J., Woessner J. F. Nomenclature and glossary of the matrix metalloproteinases // Matrix Suppl. - 1992, № 1. - P. 421-424.
24.
25. Ardans J., Economou A., Martinson J. et al. Oxidised low density and high density lipoproteins regulate the production of matrix metalloproteinases 1 and 9 by activated monocytes // J. Leukoc. Biol. - 2002. - Vol. 71, № 6. - P. 1012-1018.
26.
27. Galis Z.S., Sukhova G.K., Lark M.W. Increased expression of matrix metalloproteinase and matrix degrading activity in vulnerable regions of human atherosclerotic plaques // J. Clin. Invest. - 1994. - Vol. 94, № 6. - P. 2493-2503.
28.
29. Loftus I.M., Naylor A.R., Goodall S. et al. Increased matrix MMP9 activity in unstable carotid plaques: а potential role in acute plaque disruption // Stroke. - 2000. - Vol. 31, № 1. - P. 40-47.
30.
31. Davies M.J. Coronary disease: the pathophysiology of acute coronary syndromes // Heart. - 2000. - Vol. 83, № 3. - P. 361-366.
32.
33. Abbink J.J., Kamp A.M., Nieuwenhuys E.J. et al. Predominant role of neutrophils in the inactivation of 2-macroglobulin in arthritic joints // Arthritis Rheum. - 1992. - Vol. 34. - P. 1139-1150.
34.
35. Bonacci G.R ., Caceres L.C ., Sanchez M.C . et al. Activated alpha(2)-macroglobulin induces cell proliferation and mitogen-activated protein kinase activation by LRP-1 in the J774 macrophage-derived cell line // Arch. Biochem. Biophys. - 2007. - Vol. 460, № 1. - P. 100-106.
36.
37. Зорин Н.А., Зорина В.Н. Зорина Р.М. Роль альфа-2 макроглобулина при онкологических заболеваниях. (Обзор) // Вопр. онкологии. - 2004. - Т. 50, № 5. - С. 515-519.
38.
39. Зорин Н.А., Зорина В.Н., Зорина Р.М., Левченко В.Г. Универсальный регулятор альфа-2 макроглобулин (Обзор литературы) // Клинич. лаб. диагн. - 2004. - № 11. - С. 18-22.
Review
For citations:
Tourna A.A. Diagnostic significance of the matrix metalloproteinases 9 activity (gelatinase B) in acute coronary syndrome. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2010;16(6):582-586. (In Russ.) https://doi.org/10.18705/1607-419X-2010--6-
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