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Endothelial biomarkers as the potential indices of course of hypertension in young patients

https://doi.org/10.18705/1607-419X-2010-16-3-261-265

Abstract

Objective. To defi ne the endothelial vasoactive substances (nitric oxide, NO; and endothelin-1, ET-1), characterizing
endothelial function in young patients with arterial hypertension (АH) and to identify the diagnostically signifi cant biomarkers
of the endothelial function and their prognostic value for assessment of AH at initial stages in young patients. Design
and methods. 65 male patients with AH (age 20-45 years old), with the level of total cholesterol < 5,0 mmol/l and blood
pressure < 160/100 mmHg; and 32 healthy volunteers (mean age - 32,8  4,9 years) were enrolled. Results. Endotelial
biomarkers (NO and ET-1), characterizing the ratio vasoconstrictor agent (ET-1)/vasodilator (NO) in young patients with
AH can be considered to be a potential prognostic marker of unfavourable course of AH especially at initial stages.

About the Authors

S. V. Lyamina
Moscow State University of Medicine and Dentistry
Russian Federation


N. P. Lyamina,
Saratov Research Institute of Cardiology
Russian Federation


V. N. Senchikhin
Saratov Research Institute of Cardiology
Russian Federation


K. A. Dodina
Saratov Research Institute of Cardiology
Russian Federation


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Review

For citations:


Lyamina S.V., Lyamina, N.P., Senchikhin V.N., Dodina K.A. Endothelial biomarkers as the potential indices of course of hypertension in young patients. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2010;16(3):261-265. (In Russ.) https://doi.org/10.18705/1607-419X-2010-16-3-261-265

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