Assessment of the relationship between N-terminal pro-BNP levels and ambulatory blood pressure monitoring data in hypertensive patients
https://doi.org/10.18705/1607-419X-2010-16-3-311-315
Abstract
Objective. To study the association between N-terminal pro-brain natriuretic peptide (N-proBNP) and diurnal blood
pressure profi le in hypertensive patients. Methods and results. A total of 40 patients were included in the study. Peptide
concentration increased with age, correlated positively with diurnal pulse blood pressure variability and its mean cumulative
value over night period in hypertensive patients. In patients with high plasma concentrations of peptide its level positively
correlates with pulse blood pressure value and its variability and mean cumulative value over day period. In this subgroup
signifi cant positive correlation between N-proBNP levels and systolic blood pressure over day period was found.
pressure profi le in hypertensive patients. Methods and results. A total of 40 patients were included in the study. Peptide
concentration increased with age, correlated positively with diurnal pulse blood pressure variability and its mean cumulative
value over night period in hypertensive patients. In patients with high plasma concentrations of peptide its level positively
correlates with pulse blood pressure value and its variability and mean cumulative value over day period. In this subgroup
signifi cant positive correlation between N-proBNP levels and systolic blood pressure over day period was found.
About the Authors
A. U. Kostoeva
Russian Medical Academy of Postgraduate Education
Russian Federation
Russian Federation
A. I. Pshenytsyn
Russian Medical Academy of Postgraduate Education
Russian Federation
Russian Federation
E. A. Zolozova
Russian Medical Academy of Postgraduate Education
Russian Federation
Russian Federation
V. V. Chiginyova
Russian Medical Academy of Postgraduate Education
Russian Federation
Russian Federation
L. V. Sbrodova
Russian Medical Academy of Postgraduate Education
Russian Federation
Russian Federation
V. E. Volkov
Russian Medical Academy of Postgraduate Education
Russian Federation
Russian Federation
F. Z. Babaev
Russian Medical Academy of Postgraduate Education
Russian Federation
Russian Federation
F. M. Hezheva
Russian Medical Academy of Postgraduate Education
Russian Federation
Russian Federation
N. A. Mazour
Russian Medical Academy of Postgraduate Education
Russian Federation
Russian Federation
References
1. Конради А.О. Новая цель в лечении артериальной гипертензии - не только эффективное, но и быстрое снижение артериального давления // Артериальная гипертензия. - 2008. - Т. 14, № 2. - С. 137-142.
2.
3. Lucher A., Stevens T.L., Borgeson D.D. et al. Differential atrial and ventricular expression of myocardial BNP during evolution of heart failure // Am. J. Physiol. - 1998. - Vol. 274. - Р. 1684-1689.
4.
5. Magga J., Martilla M., Mantyma P. et al. Brain natriuretic peptide in plasms, atria, and ventricles of vasopressin- and phenylephrine-infused conscious rats // Endocrinology. - 1994. - Vol. 134. - Р. 2505-2515.
6.
7. Suga S., Nakao K., Hosoda K. et al. Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide // Endocrinology. - 1992. - Vol. 130, № 1. - Р. 229-239
8.
9. Bettencourt P., Ferreira A., Sousa T. et al. Brain natriuretic peptide as a marker of cardiac involvement in hypertension // Int. J. Cardiol. - 1999. - Vol. 69, № 2. - Р. 167-177.
10.
11. Hildebrandt P., Boesen M., Olsen M. N-terminal pro-brain natriuretic peptide in arterial hypertension - a marker for left ventricular dimensions and prognosis // Eur. J. Heart Fail. - 2004. - Vol. 6, № 3. - Р. 313-317.
12.
13. Nishikimi Т., Yoshihara F., Jshikawa K. et al. Relationship between left ventricular geometry and natriuretic peptide levels in essential hypertension // Hypertension. - 1996. - Vol. 28, № 1. - P. 22-30.
14.
15. Talwar S., Siebenhofer A., Williams B., Ng L. Infl uence of hypertension, left ventricular hypertrophy, and left ventricular systolic dysfunction on plasma N-terminal pro BNP // Heart. - 2000. - Vol. 83. - Р. 278-282.
16.
17. Чазов Е.И., Чазова И.Е. Руководство по артериальной гипертонии. - М.: МедиаМедика, 2005. - 324-341с.
18.
19. Vanderheyden M., Bartunek J., Goethals M. Brain and other natriuretic peptides: molecular aspects // Eur. J. Heart Fail. - 2004. - Vol. 6, № 3. - Р. 261-268.
20.
21. Asmar R., Rudnichi A., Blacher J. et al. Pulse pressure and aortic pulse wave are markers of cardiovascular risk in hypertensive populations // Am. J. Hypertens. - 2001. - Vol. 14, № 2. - Р. 91-97.
22.
23. Mottram P., Leano R., Marwick T. Usefulness of B-type natriuretic peptide in hypertensive patients with exertional dyspnea and normal left ventricular ejection fraction and correlation with new echocardiographic indexes of systolic and diastolic function // Am. J. Cardiol. - 2003. - Vol. 92, № 12. - Р. 224-230.
24.
25. Palatini P., Mormino P., Santonastaso M. et al. Ambulatory blood pressure predicts end-organ damage only in subjects with reproducible recordings // Hypertension. - 1999. - Vol. 17, № 4. - Р. 465-473.
26.
27. Рогоза А.Н., Никольский В.П., Дмитриев В.В. Суточное мо- ниторирование артериального давления (методические вопросы) / Под ред. Г.Г. Арабидзе, О.Ю. Атькова. - М.: AND, 1997. - 44 с.
28.
29. ОBraian E., Cayle D. Ambulatory blood pressure measurement and the occurrence of hypertensive organ involment // Neth. J. Med. - 1995. - Vol. 47, № 4. - Р. 145-151.
30.
Review
For citations:
Kostoeva A.U., Pshenytsyn A.I., Zolozova E.A., Chiginyova V.V., Sbrodova L.V., Volkov V.E., Babaev F.Z., Hezheva F.M., Mazour N.A. Assessment of the relationship between N-terminal pro-BNP levels and ambulatory blood pressure monitoring data in hypertensive patients. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2010;16(3):311-315. (In Russ.) https://doi.org/10.18705/1607-419X-2010-16-3-311-315
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