CHANGES OF THE SYMPATHETIC ACTIVITY IN THE HEART AND VESSELS IN THE DEVELOPMENT OF EXPERIMENTAL VASORENAL HYPERTENSION (2 KIDNEYS — 1 CLIP)
https://doi.org/10.18705/1607-419X-2014-20-6-515-521
Abstract
Objective. To evaluate the dynamics of arterial blood pressure and sympathetic activity in the male Wistar rats within 8 weeks after renal artery clamping (model «2 kidneys — 1 clamp»).
Design and methods. The sympathetic activity was examined by spectral analysis of the heart rate variability in the non-anaesthesized rats. The sympathetic vasomotor activity was examined by the registration of electric activity of the cervical spine cord in anaesthesized animals.
Results. We found that sympathetic activity to the heart and blood vessels is comparable. Two weeks after renal artery clamping the activity of the sympathetic nervous system increases, and 4 weeks later it comes close to the reference values in the developed hypertension and then increases to maximum values by the end of the experiment.
About the Authors
N. V. Kuzmenko
Federal Almazov Medical Research Centre, St Petersburg ;
First Pavlov State Medical University of St. Petersburg, St Petersburg
Russian Federation
Russian Federation
Corresponding author: Natalia V. Kuzmenko, PhD of Biology Sciences, Federal Almazov Medical Research Centre, 2 Akkuratova street, St Petersburg, 197341 Russia. E-mail: kuzmenko@niiekf.ru
Y. I. Shcherbin
Federal Almazov Medical Research Centre, St Petersburg ;
First Pavlov State Medical University of St. Petersburg, St Petersburg
Russian Federation
Russian Federation
PhD, Biology Sciences, Senior Researcher, Department of Experimental Physiology and Pharmacology;
Laboratory of Circulation Biophysics
M. G. Pliss
Federal Almazov Medical Research Centre, St Petersburg ;
First Pavlov State Medical University of St. Petersburg, St Petersburg
Russian Federation
Russian Federation
MD, PhD, Head, Department of Experimental Physiology and Pharmacology;
Laboratory of Circulation Biophysics
V. A. Tsyrlin
Federal Almazov Medical Research Centre, St Petersburg ;
First Pavlov State Medical University of St. Petersburg, St Petersburg
Russian Federation
Russian Federation
MD, PhD, DSc, Professor, Leading Researcher, Department of Experimental Physiology and Pharmacology;
Department of Pharmacology
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Review
For citations:
Kuzmenko N.V., Shcherbin Y.I., Pliss M.G., Tsyrlin V.A. CHANGES OF THE SYMPATHETIC ACTIVITY IN THE HEART AND VESSELS IN THE DEVELOPMENT OF EXPERIMENTAL VASORENAL HYPERTENSION (2 KIDNEYS — 1 CLIP). "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2014;20(6):515-521. https://doi.org/10.18705/1607-419X-2014-20-6-515-521
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