Analysis of the input of polymorphism of several candidate genes in the development of hypertension and myocardial remodeling: in the sample of sibling pairs
https://doi.org/10.18705/1607-419X-2011-17-5-488-492
Abstract
Objective. To assess the contribution of the renin-angiotensin system, lipid metabolism and gene regulators of apoptosis in the development of hypertension and myocardial remodeling using sibling-pair and associative methods. Design and methods. Myocardial mass and myocardial mass index were calculated by echocardiography method, gene polymorphism was identified by polymerase chain reaction. Results. We found the association of genotype M235M AGT gene with hypertension in representatives of the Tatar ethnic group. Genotype A603A gene EAAT2 is associated with higher systolic blood pressure, and genotype CC rs189994 AIF gene is related to the greater myocardial mass in hypertensive patients.
About the Authors
N. R. Khasanov
GBOU VPO «Kazan State Medical University», Department of the Internal Medicine Propaedeutics
Russian Federation
Russian Federation
V. N. Oslopov
GBOU VPO «Kazan State Medical University», Department of the Internal Medicine Propaedeutics
Russian Federation
Russian Federation
P. A. Slominskiy
Institution of the Russian Academy of Sciences «Institute of Molecular Genetics of RAS»
Russian Federation
Russian Federation
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Review
For citations:
Khasanov N.R., Oslopov V.N., Slominskiy P.A. Analysis of the input of polymorphism of several candidate genes in the development of hypertension and myocardial remodeling: in the sample of sibling pairs. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2011;17(5):488-492. (In Russ.) https://doi.org/10.18705/1607-419X-2011-17-5-488-492
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