Механизмы развития резистентности к антигипертензивной терапии при синдроме обструктивного апноэ во время сна
Аннотация
В обзоре обсуждаются возможные механизмы, лежащие в основе формирования резистентности к антигипертензивной терапии у больных с синдромом обструктивного апноэ во время сна (СОАС) и артериальной гипертензией (АГ). Приводятся данные о более выраженном поражении органов-мишеней, которое можно частично объяснить активацией воспалительных процессов, эндотелиальной дисфункцией вследствие повторных эпизодов гипоксии, а также особенностями АГ у пациентов с СОАС. Активация ренин-ангиотензин-альдостероновой системы с повышением уровня альдостерона, помимо отрицательного влияния на сердечно-сосудистую систему, усугубляет течение самого СОАС.
Об авторах
Н. Э. Звартау
ФГБУ «Федеральный Центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздравсоцразвития РФ
Россия
Россия
Ю. В. Свиряев
ФГБУ «Федеральный Центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздравсоцразвития РФ
Россия
Россия
Л. С. Коростовцева
ФГБУ «Федеральный Центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздравсоцразвития РФ
Россия
Россия
А. О. Конради
ФГБУ «Федеральный Центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздравсоцразвития РФ
Россия
Россия
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Для цитирования:
Звартау Н.Э., Свиряев Ю.В., Коростовцева Л.С., Конради А.О. Механизмы развития резистентности к антигипертензивной терапии при синдроме обструктивного апноэ во время сна. Артериальная гипертензия. 2012;18(3):184-190. https://doi.org/10.18705/1607-419X-2012-18-3-184-190
For citation:
Zvartau N.E., Sviryaev Y.V., Korostovtseva L.S., Konradi A.O. Possible mechanisms of drug-resistance in hypertensive patients with obstructive sleep apnea. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2012;18(3):184-190. (In Russ.) https://doi.org/10.18705/1607-419X-2012-18-3-184-190
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