Механизмы развития резистентности к антигипертензивной терапии при синдроме обструктивного апноэ во время сна
https://doi.org/10.18705/1607-419X-2012-18-3-184-190
Аннотация
В обзоре обсуждаются возможные механизмы, лежащие в основе формирования резистентности к антигипертензивной терапии у больных с синдромом обструктивного апноэ во время сна (СОАС) и артериальной гипертензией (АГ). Приводятся данные о более выраженном поражении органов-мишеней, которое можно частично объяснить активацией воспалительных процессов, эндотелиальной дисфункцией вследствие повторных эпизодов гипоксии, а также особенностями АГ у пациентов с СОАС. Активация ренин-ангиотензин-альдостероновой системы с повышением уровня альдостерона, помимо отрицательного влияния на сердечно-сосудистую систему, усугубляет течение самого СОАС.
Об авторах
Н. Э. Звартау
ФГБУ «Федеральный Центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздравсоцразвития РФ
Россия
Россия
Ю. В. Свиряев
ФГБУ «Федеральный Центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздравсоцразвития РФ
Россия
Россия
Л. С. Коростовцева
ФГБУ «Федеральный Центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздравсоцразвития РФ
Россия
Россия
А. О. Конради
ФГБУ «Федеральный Центр сердца, крови и эндокринологии им. В.А. Алмазова» Минздравсоцразвития РФ
Россия
Россия
Список литературы
1. Sjostrom C., Lindberg E., Elmasry A., Hagg A., Svardsudd K., Janson C. Prevalence of sleep apnoea and snoring in hypertensive men: a population based study // Thorax. — 2002. — Vol. 57, № 7. — Р 602-607.
2. Gon9alves S.C., Martinez D., Gus M. et al. Obstructive sleep apnea and resistant hypertension: a case-control study // Chest. — 2007. — Vol. 132, № 6. — P. 1858-1862.
3. Duran-Cantolla J., Aizpuru F., Martinez-Null C., Barbe-Illa F. Obstructive sleep apnea/hypopnea and systemic hypertension // Sleep Med. Rev. — 2009. — Vol. 13, № 5. — P. 323-331.
4. Drager L.F., Genta P.R., Pedrosa R.P. et al. Characteristics and predictors of obstructive sleep apnea in patients with systemic hypertension // Am. J. Cardiol. — 2010. — Vol. 105, № 8. — P. 1135-1139.
5. Calhoun D.A., Harding S.M. Sleep and hypertension // Chest. — 2010. — Vol. 138, № 2. — P. 434-443.
6. Coughlin S.R., Mawdsley L., Mugarza J.A., Wilding J.P.H., Calverley P.M.A. Cardiovascular and metabolic effects of CPAP in obese males with OSA // Eur. Resp. J. — 2007. — Vol. 29, № 4. — P. 720-727.
7. Schwartz A., Gold A., Schubert N. et al. Effect ofweight loss on upper airway collapsibility in obstructive sleep apnea // Am. Rev. Respir. Dis. — 1991. — Vol. 144, № 3, Pt. 1. — P. 494-498.
8. Vgontzas A.N., Papanicolaou D.A., Bixler E.O. et al. Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance and hypercytokinemia // J. Clin. Endocrinol. Metab. — 2000. — Vol. 85, № 3. — P. 1151-1158.
9. Wolk R., Shamsuzzaman A.S., Somers V.K. Obesity, sleep apnea, and hypertension // Hypertension. — 2003. — Vol. 42, № 6. — P. 1067-1078.
10. Salvador J., Iriarte J., Silva C. ct al. The obstructive sleep apnoea syndrom in obesity: a conspirator in the shadow // Med. Univ. Neverra. — 2004. — Vol. 48, № 2. — P. 55-62.
11. Somers V.K., White D.P., Amin R. et al. Sleep apnea and cardiovascular disease: an American Heart Association/American College Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council On Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health) // Circulation. — 2008. — Vol. 118, № 10. — P. 1080-1111.
12. Phillips B.G., Kato M., Narkiewicz K. et al. Increases in leptin levels, sympathetic drive, and weight gain in obstructive sleep apnea // Am. J. Physiol. — 2000. — Vol. 279, № 1. — P. H234-H237.
13. Chin K., Shimizu K., Nakamura T. et al. Changes in intraabdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy // Circulation. — 1999. — Vol. 100, № 7. — P. 706-712.
14. Calhoun D.A., Jones D., Textor S. Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research // Circulation. — 2008. — Vol. 117, № 25. — P. 510-526.
15. Faulx M.D., Storfer-Isser A., Kirchner H.L., Jenny N.S., Tracy R.P., Redline S. Obstructive sleep apnea is associated with increased urinary albumin excretion // Sleep. — 2007. — Vol. 117, № 7. — 923-929.
16. Drager L.F., Bortolotto L.A., Figueiredo A.C., Silva B.C., Krieger E.M., Lorenzi-Filho G. Obstructive sleep apnea, hypertension, and their interaction on arterial stiffness and heart remodeling // Chest. — 2007. — Vol. 131, № 5. — P. 13791386.
17. Drager L.F., Bortolotto L.A., Pedrosa R.P., Krieger E.M., Lorenzi-Filho G. Left atrial diameter is independently associated with arterial stiffness in patients with obstructive sleep apnea: potential implications for atrial fibrillation // Int. J. Cardiol. — 2010. — Vol. 144, № 2. — P. 257-259.
18. Pedrosa R.P., Drager L.F., Genta P.R. et al. Obstructive sleep apnea is common and independently associated with atrial fibrillation in patients with hypertrophic cardiomyopathy // Chest. — 2010. — Vol. 137, № 5. — P. 1078-1084.
19. Kato M., Roberts-Thomson P., Phillips B.G. et al. Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea // Circulation. — 2000. — Vol. 102, № 21. — P. 2607-2610.
20. Ip M.S., Tse H.F., Lam B., Tsang K.W., Lam W.K. Endothelial function in obstructive sleep apnea and response to treatment // Am. J. Respir. Crit. Care Med. — 2004. — Vol. 169, № 3. — P. 348-353.
21. Jelic S., Lederer D.J., Adams T. et al. Vascular inflammation in obesity and sleep apnea // Circulation. — 2010. — Vol. 121, № 8. — P. 1014-1021.
22. Kraiczi H., Caidahl K., Samuelsson A., Peker Y., Hedner J. Impairment of vascular endothelial function and left ventricular filling: association with the severity of apnea-induced hypoxemia during sleep // Chest. — 2001. — Vol. 119, № 4. — P. 1085-1091.
23. Phillips B.G., Narkiewicz K., Pesek C.A., Haynes W.G., Dyken M.E., Somers V.K. Effects of obstructive sleep apnea on endothelin-1 and blood pressure // J. Hypertens. — 1999. — Vol. 17, № 1. — P. 61-66.
24. Gjorup P.H., Sadauskiene L., Wessels J., Nyvad O., Strunge B., Pedersen E.B. Abnormally increased endothelin-1 in plasma during the night in obstructive sleep apnea: relation to blood pressure and severity of disease // Am. J. Hypertens. — 2007. — Vol. 20, № 1. — P. 44-52.
25. Zhang X.L., Yin K.S., Mao H., Wang H., Yang Y. Effect of continuous positive airway pressure treatment on vascular endothelial function in patients with obstructive sleep apnea hypopnea syndrome and coronary artery disease // Chin. Med. J. (Engl.). — 2004. — Vol. 117, № 6. — P. 844-847.
26. Jelic S., Padeletti M., Kawut S.M. et al. Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea // Circulation. — 2008. — Vol. 117, № 17. — P. 2270-2278.
27. Imoberdorf R., Garlick P.J., McNurian M.A. et al. Enhanced synthesis of albumin and fibrinogen at high altitude // J. Appl. Physiol. — 2001. — Vol. 90, № 2. — P. 526-537.
28. Lavie L., Vishnevsky A., Lavie P. Evidence for lipid peroxidation in obstructive sleep apnea // Sleep. — 2004. — Vol. 27, № 1. — Р. 123-128.
29. Shamsuzzaman A.S., Winnicki M., Lanfranchi P., Wolk R., Kara T., Accurso V., Somers V.K. Elevated C-reactive protein in patients with obstructive sleep apnea // Circulation. — 2002. — Vol. 105, № 21. — P. 2462-2464.
30. Svatikova A., Wolk R., Shamsuzzaman A.S., Kara T., Olson E.J., Somers V.K. Serum amyloid a in obstructive sleep apnea // Circulation. — 2003. — Vol. 108, № 12. — P. 1451-1454.
31. Lavie L., Hefetz A., Luboshitzky R., Lavie P. Plasma levels of nitric oxide and L-arginine in sleep apnea patients: effects of nCPAP treatment // J. Mol. Neurosci. — 2003. — Vol. 21, № 1. — P. 57-64.
32. Schulz R., Mahmoudi S., Hattar K. et al. Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea. Impact of continuous positive airway pressure therapy // Am J Respir Crit Care Med. — 2000. — Vol. 162, № 2, Pt. 1. — P. 566-570.
33. Dyugovskaya L., Lavie P., Lavie L. Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients // Am. J. Respir. Crit. Care Med. — 2002. — Vol. 165, № 7. — P. 934-939.
34. Dyugovskaya L., Lavie P., Lavie L. Phenotypic and functional characterization of blood gammadelta T cells in sleep apnea // Am. J. Respir. Crit. Care Med. — 2003. — Vol. 168, № 2. — P. 242-249.
35. Silvestrini M., Rizzato B., Placidi F., Baruffaldi R., Bianconi A., Diomedi M. Carotid artery wall thickness in patients with obstructive sleep apnea syndrome // Stroke. — 2002. — Vol. 33, № 7. — P. 1782-1785.
36. Friedlander A.H., Friedlander I.K., Yueh R., Littner M.R. The prevalence of carotid atheromas seen on panoramic radiographs of patients with obstructive sleep apnea and their relation to risk factors for atherosclerosis // J. Oral Maxillofac. Surg. — 1999. — Vol. 57, № 5. — P. 516-521.
37. Shearer W.T., Reuben J.M., Mullington J.M. et al. Soluble TNF-alpha recedptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight // J. Allergy Clin. Immunol. — 2001. — Vol. 107, № 1. — P. 165-170.
38. Meier-Ewert H.K., Ridker P.M., Rifai N. et al. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk // J. Am. Coll. Cardiol. — 2004. — Vol. 43, № 4. — P. 678-683.
39. Amagai Y., Ishikawa S., Gotoh T. et al. Sleep duration and mortality in Japan: The Jichi Medical School Cohort Study // J. Epidemiol. — 2004. — Vol. 14, № 4. — P. 124-130.
40. Opp M.R., Kapas L., Toth L.A. Cytokine involvement in the regulation of sleep // Proc. Soc. Exp. Biol. Med. — 1992. — Vol. 201, № 1. — P. 16-27.
41. Ishida K., Kato M., Kato Y. et al. Appropriate use of nasal continuous positive airway pressure decreases elevated C-reactive protein in patients with obstructive sleep apnea // Chest. — 2009. — Vol. 136, № 1. — P. 125-129.
42. de Lima A.M., Franco C.M., de Castrol C.M., Bezerra A.D., Ataide L., Jr,, Halpern A. Effects of nasal continuous positive airway pressure treatment on oxidative stress and adiponectin levels in obese patients with obstructive sleep apnea // Respiration. — 2010. — Vol. 79, № 5. — P. 370-376.
43. Phillips C.L., Yang Q., Williams A. et al. The effect of shortterm withdrawal from continuous positive airway pressure therapy on sympathetic activity and markers of vascular inflammation in subjects with obstructive sleep apnoea // J. Sleep Res. — 2007. — Vol. 16, № 2. — P. 217-225.
44. Drager L.F., Bortolotto L.A., Figueiredo A.C., Krieger E.M., Lorenzi G.F. Effects of continuous positive airway pressure on early signs of atherosclerosis in obstructive sleep apnea // Am. J. Respir. Crit. Care Med. — 2007. — Vol. 176, № 7. — P. 706-712.
45. Kitahara Y., Hattori N., Yokoyama A., Nakajima M., Kohno N. Effect of CPAP on brachial-ankle pulse wave velocity in patients with OSAHS: an open-labelled study // Respir. Med. — 2006. — Vol. 100, № 12. — P. 2160-2169.
46. Drager L.F., Diegues-Silva L., Diniz P.M. et al. Obstructive sleep apnea, masked hypertension, and arterial stiffness in men // Am. J. Hypertens. — 2010. — Vol. 23, № 3. — P. 249-254.
47. Baguet J.P., Hammer L., Levy P. et al. Night-time and diastolic hypertension are common and underestimated conditions in newly diagnosed apnoeic patients // J. Hypertens. — 2005. — Vol. 23, № 3. — P. 521-527.
48. Sharabi Y., Scope A., Chorney N., Grotto I., Dagan Y. Diastolic blood pressure is the first to rise in association with early subclinical obstructive sleep apnea: lessons from periodic examination screening // Am. J. Hypertens. — 2003. — Vol. 16, № 3. — P. 236-239.
49. Haas D.C., Foster G.L., Nieto F.J. et al. Age-dependent associations between sleep-disordered breathing and hypertension // Circulation. — 2005. — Vol. 111, № 5. — P. 614-621.
50. Kapa S., Sert Kuniyoshi F.H., Somers V.K. Sleep apnea and hypertension: interactions and implications for management // Hypertension. — 2008. — Vol. 51, № 3. — P. 605-608.
51. Armario P., Hernandez del Rey R. Variability of arterial pressure // Nefrologia. — 2002. — Vol. 22, Suppl. 3. — P. 54-58.
52. Verdecchia P., Schillaci G., Guerrieri M. et al. Circadian blood pressure changes and left ventricular hypertrophy in essential hypertension // Circulation. — 1990. — Vol. 81, № 2. — P. 528-536.
53. Verdecchia P. Left ventricular mass in dippers and nondippers // J. Hypertens. — 1995. — Vol. 13, № 12. — P. 14811483.
54. Ohkubo T., Hozawa A., Nagai K. et al. Prediction of stroke by ambulatory blood pressure monitoring versus screening blood pressure measurements in a general population: the Ohasama study // J. Hypertens. — 2000. — Vol. 18, № 7. — P. 847-854.
55. Dolan E., Stanton A.V., Thom S. et al. ASCOT Investigators Ambulatory blood pressure monitoring predicts cardiovascular events in treated hypertensive patients-an Anglo-Scandinavian cardiac outcomes trial substudy // J. Hypertens. — 2009. — Vol. 27, № 4. — P. 876-885.
56. Kario K., Pickering T.G., Matsuo T., Hoshide S., Schwartz J.E., Shimada K. Stroke prognosis and abnormal nocturnal blood pressure falls in older hypertensives // Hypertension. — 2001. — Vol. 38, № 4. — P. 852-857.
57. Ben-Dov I.Z., Kark J.D., Ben-Ishay D., Mekler J., Ben-Arie L., Bursztyn M. Predictors of all-cause mortality in clinical ambulatory monitoring: unique aspects of blood pressure during sleep // Hypertension. — 2007. — Vol. 49, № 6. — P. 1235-1241.
58. Pratt-Ubunama M.N., Nishizaka M.K., Boedefeld R.L., Cofield S.S., Harding S.M., Calhoun D.A. Plasma aldosterone is related to severity of obstructive sleep apnea in subjects with resistant hypertension // Chest. — 2007. — Vol. 131, № 2. — P. 453-459.
59. Calhoun D.A., Nishizaka M.K., Zaman M.A., Harding S.M. Aldosterone excretion among subjects with resistant hypertension and symptoms of sleep apnea // Chest. — 2004. — Vol. 125, № 1. — P. 112-117.
60. Chiu K.L., Ryan C.M., Shiota S. et al. Fluid shift by lower body airway cross-sectional increases pharyngeal resistance in healthy subjects // Am. J. Respir. Crit. Care Med. — 2006. — Vol. 174, № 12. — P. 1378-1383.
61. Bucca C.B., Brussino L., Battisti A. et al. Diuretics in obstructive sleep apnea with diastolic heart failure // Chest. — 2007. — Vol. 132, № 2. — P. 440-446.
62. Gaddam K., Pimenta E., Thomas S.J. et al. Spironolactone reduces severity of obstructive sleep apnea in patients with resistant hypertension: a preliminary report // J. Hum. Hypertens. — 2010. — Vol. 24, № 8. — P. 532-537.
Рецензия
Для цитирования:
Звартау Н.Э., Свиряев Ю.В., Коростовцева Л.С., Конради А.О. Механизмы развития резистентности к антигипертензивной терапии при синдроме обструктивного апноэ во время сна. Артериальная гипертензия. 2012;18(3):184-190. https://doi.org/10.18705/1607-419X-2012-18-3-184-190
For citation:
Zvartau N.E., Sviryaev Yu.V., Korostovtseva L.S., Konradi A.O. Possible mechanisms of drug-resistance in hypertensive patients with obstructive sleep apnea. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2012;18(3):184-190. (In Russ.) https://doi.org/10.18705/1607-419X-2012-18-3-184-190
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