Blood pressure, lipid levels and apolipoprotein A1 and paraoxonase 1 gene polymorphisms in patients with abdominal obesity
https://doi.org/10.18705/1607-419X-2012-18-3-255-266
Abstract
Objective. To evaluate G-75A and C+83T polymorphisms of apolipoprotein A1 gene and Q192R polymorphism of paraoxonase 1 gene and their association with blood pressure and lipid levels in patients with abdominal obesity. Design and methods. We examined 222 obese patients (57 males and 165 females), residents of St Petersburg, Russian Federation. Results. High incidence of arterial hypertension (61 %) and dyslipidemia of different types was revealed. The frequency of different alleles of apolipoprotein A1 and paraoxonase 1 genes was analyzed. The results of gene-gene interactions and their associations with blood pressure, obesity and lipids profiles are presented.
About the Authors
H. .. An-Hahar
vlov St Petersburg State Medical University, St Petersburg
Russian Federation
Russian Federation
O. O. Bolshakova
Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg
Russian Federation
Russian Federation
O. D. Belyaeva
vlov St Petersburg State Medical University, St Petersburg
Russian Federation
Russian Federation
O. A. Berkovich
vlov St Petersburg State Medical University, St Petersburg
Russian Federation
Russian Federation
V. I. Larionova
St Petersburg State Pediatric Medical Academy
Russian Federation
Russian Federation
E. I. Baranova
vlov St Petersburg State Medical University, St Petersburg; Almazov Federal Heart, Blood and Endocrinology Centre, St Petersburg
Russian Federation
Russian Federation
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Review
For citations:
An-Hahar H..., Bolshakova O.O., Belyaeva O.D., Berkovich O.A., Larionova V.I., Baranova E.I. Blood pressure, lipid levels and apolipoprotein A1 and paraoxonase 1 gene polymorphisms in patients with abdominal obesity. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2012;18(3):255-266. (In Russ.) https://doi.org/10.18705/1607-419X-2012-18-3-255-266
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