Analysis of gene-gene interactions of polymorphic cytokine genes loci in patients with essential hypertension
https://doi.org/10.18705/1607-419X-2012-18-5-443-448
Abstract
Background. Chronic systemic inflammation is a key factor in the pathogenesis of cardiovascular diseases. The exact mechanisms underlying blood pressure elevation are unclear, but recent findings suggest that inflammatory mediators are involved. The objective of our study was to investigate the influence of gene-gene interactions between IL6, IL1B, IL12B, TNF, LTA and IL10 genes polymorphic markers on susceptibility to essential hypertension. Results. In the ethnic group of Tatars residing in Bashkortostan, Russia, we found an association of IL1B rs16944 and IL10 rs1800872 polymorphic markers with the disease. The analysis of gene-gene interactions showed significant synergy between IL12B rs3212227 and TNF rs1800629 polymorphic markers towards essential hypertension. The final model (logistic regression) included IL10 rs1800872 genetic marker and the combination of IL12B rs3212227 and TNF rs1800629 genetic markers as optimal predictors of essential hypertension. Conclusion. Our data confirm the involvement of cytokine system in the development of essential hypertension.
About the Authors
Y. R. Timasheva
Institute of Biochemistry and Genetics Ufa Scientific Centre Russian Academy of Science
Russian Federation
Russian Federation
T. R. Nasibullin
Institute of Biochemistry and Genetics Ufa Scientific Centre Russian Academy of Science
Russian Federation
Russian Federation
I. A. Tuktarova
Institute of Biochemistry and Genetics Ufa Scientific Centre Russian Academy of Science
Russian Federation
Russian Federation
I. M. Karamova
Republic Centre of Cardiology, Ufa
Russian Federation
Russian Federation
A. N. Petrin
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Russian Federation
Russian Federation
O. E. Mustafina
Institute of Biochemistry and Genetics Ufa Scientific Centre Russian Academy of Science
Russian Federation
Russian Federation
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Review
For citations:
Timasheva Y.R., Nasibullin T.R., Tuktarova I.A., Karamova I.M., Petrin A.N., Mustafina O.E. Analysis of gene-gene interactions of polymorphic cytokine genes loci in patients with essential hypertension. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2012;18(5):443-448. (In Russ.) https://doi.org/10.18705/1607-419X-2012-18-5-443-448
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