Histological characteristics of human renal artery nerves and neural ganglia
https://doi.org/10.18705/1607-419X-2018-24-5-515-520
Abstract
Objective. Understanding of nerve and ganglia distribution in human renal arteries is essential in effective transcatheter denervation procedures. The purpose of the study was histological characterization of nerves and ganglia in human renal artery. Design and methods. Histological study included 29 proximal renal artery sections obtained from 20 patients with different cardiovascular diseases. Results. We identified 1203 nervous elements, of them fibers — 1148, ganglia — 55 (4 %). The range of distances from intima to nerves was 0,3–8,8 mm [1,4 (1,0; 1,9) mm]; the range of distances from intima to ganglia was 0,6–4,5 mm [2,2 (1,4; 2,7) mm]. The majority among nerve elements (93 %) were located at a depth of 3 mm from artery lumen. Conclusions. The majority of nervous elements of renal arteries is located within 3 mm deep from artery lumen.
About the Authors
K. E. Ivanov
Almazov National Medical Research Centre.
Russian Federation
Russian Federation
Konstantin E. Ivanov, MD, PhD student, Research Department for Arrhythmology.
2 Akkuratov street, St Petersburg, 197341.
L. B. Mitrofanova
Almazov National Medical Research Centre.
Russian Federation
Russian Federation
Lubov B. Mitrofanova, MD, PhD, DSc, Head, Research Laboratory of Pathology.
2 Akkuratov street, St Petersburg, 197341.
S. V. Garkina
Almazov National Medical Research Centre.
Russian Federation
Russian Federation
Svetlana V. Garkina, MD, PhD, Senior Researcher, Research Laboratory for Neuromodulation, Research Department for Intervention Arrhythmology.
2 Akkuratov street, St Petersburg, 197341.
E. N. Mikhaylov
Almazov National Medical Research Centre.
Russian Federation
Russian Federation
Eugeny N. Mikhaylov, MD, PhD, DSc, Head, Research Laboratory for Neuromodulation, Research Department for Intervention Arrhythmology.
2 Akkuratov street, St Petersburg, 197341.
D. S. Lebedev
Almazov National Medical Research Centre.
Russian Federation
Russian Federation
Dmitry S. Lebedev, MD, PhD, DSc, Professor, Head, Research Department for Arrhythmology.
2 Akkuratov street, St Petersburg, 197341.
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Review
For citations:
Ivanov K.E., Mitrofanova L.B., Garkina S.V., Mikhaylov E.N., Lebedev D.S. Histological characteristics of human renal artery nerves and neural ganglia. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2018;24(5):515-520. (In Russ.) https://doi.org/10.18705/1607-419X-2018-24-5-515-520
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