Triple fixed combination for hypertension treatment — a green light in the new european Guidelines 2018
https://doi.org/10.18705/1607-419X-2018-24-6-716-722
Abstract
The majority of patients with stable arterial hypertension require combination therapy which is supported by the clinical evidence. The established target levels of blood pressure below 130/80 mmHg are challenging and demand multiple drug combinations in a single patient. Therefore, the use of dual and triple combination therapy is getting wider, and rational triple fixed combinations are highly relevant. The updated guidelines on the diagnostics, management and treatment of arterial hypertension of the European Society of Hypertension and the European Society of Cardiology confirm and recommend early and wider use of the fixed-dose drug combinations. The paper reviews the main practical issues of the use of combination therapy, including key questions of the change from free dose to fixed dose combinations and their rational choice.
About the Author
A. O. Konradi
Almazov National Medical Research Centre; ITMO University.
Russian Federation
Russian Federation
Aleksandra O. Konradi, MD, PhD, DSc, Professor, Corresponding Member of RAS; the Deputy Director General of Science, Almazov National Medical Research Centre; Head, Translational Medicine Institute; ITMO University.
2 Akkuratov street, St Petersburg, 197341.
References
1. Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018;39(33);3021–3104. doi: 10.1093/eurheartj/ehy339
2. Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, et al. 2013 ESH/ESC guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 2013;34(28):2159–219. doi: 10.1093/eurheartj/eht151
3. Wald DS, Law M, Morris JK, Bestwick JP, Wald NJ. Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11,000 participants from 42 trials. Am J Med. 2009;122(3):290–300. doi: 10.1016/j.amjmed.2008.09.038
4. Weir MR, Hsueh WA, Nesbitt SD, Littlejohn TJ III, Graff A, Shojaee A et al. A titrate-to-goal study of switching patients uncontrolled on antihypertensive monotherapy to fixed-dose combinations of amlodipine and olmesartan medoxomil ± hydrochlorothiazide. J Clin Hypertens (Greenwich). 2011;13(6):404–412. doi: 10.1111/j.1751-7176.2011.00437.x
5. Volpe M, Christian Rump L, Ammentorp B, Laeis P. Efficacy and safety of triple antihypertensive therapy with the olmesartan/amlodipine/hydrochlorothiazide combination. Clin Drug Investig. 2012;32(10):649–664. doi: 10.2165/11636320-000000000-0000
6. Corrao G, Parodi A, Zambon A, Heiman F, Filippi A, Cricelli C et al. Reduced discontinuation of antihypertensive treatment by two-drug combination as first step. Evidence from daily life practice. J Hypertens. 2010;28(7):1584–1590. doi: 10.1097/HJH.0b013e328339f9fa
7. Gupta AK, Arshad S, Poulter NR. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis. Hypertension. 2010;55(2):399–407. doi: 10.1161/HYPERTENSIONAHA.109.139816
8. Jung O, Gechter JL, Wunder C, Paulke A, Bartel C, Geiger H et al. Resistant hypertension? Assessment of adherence by toxicological urine analysis. J Hypertens. 2013;31(4):766–774. doi: 10.1097/HJH.0b013e32835e228
9. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119–177. doi: 10.1093/eurheartj/ehx393
10. Gupta P, Patel P, Horne R, Buchanan H, Williams B, Tomaszewski M. How to screen for non-adherence to antihypertensive therapy. Curr Hypertens Rep. 2016;18(12):89.
11. Coca A, Agabiti-Rosei E, Cifkova R, Manolis AJ, Redon J, Mancia G. The polypill in cardiovascular prevention: evidence, limitations and perspective - position paper of the European Society of Hypertension. J Hypertens. 2017;35(8):1546–1553. doi: 10.1097/HJH.0000000000001390
12. Chalmers J, Arima H, Woodward M, Mancia G, Poulter N, Hirakawa Y et al. Effects of combination of perindopril, indapamide, and calcium channel blockers in patients with type 2 diabetes mellitus: results from the Action In Diabetes and Vascular Disease: Preterax and Diamicron Controlled Evaluation (ADVANCE) trial. Hypertension. 2014;63(2):259-264. doi: 10.1161/HYPERTENSIONAHA.113.02252
Review
For citations:
Konradi A.O. Triple fixed combination for hypertension treatment — a green light in the new european Guidelines 2018. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2018;24(6):716-722. (In Russ.) https://doi.org/10.18705/1607-419X-2018-24-6-716-722
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