Replicative cell ageing: the role of insulin resistance in patients with arterial hypertension
E. N. Dudinskaya,
O. N. Tkacheva,
L. V. Matchekhina,
Yu. V. Kotovskaya,
I. V. Leonteva,
I. A. Kovalev,
M. A. Shkolnikova https://doi.org/10.18705/1607-419X-2019-25-3-225-231
Abstract
The review presents basic information about the processes of replicative cellular and vascular aging. Special attention is paid to the problem of hypertension and insulin resistance. The mechanisms of the onset of insulin resistance and hypertension, their role in the development of major age-related vascular changes, the transformation of vascular aging into disease, and their contribution to life expectancy are discussed. Possible ways of influencing these processes are considered.
About the Authors
E. N. Dudinskaya
Pirogov Russian National Research Medical University of Ministry of Health of Russian federation Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
Ekaterina N. Dudinskaya - MD, PhD, Head, Laboratory of the Age-related Metabolic and Endocrine Disorders.
16, 1st Leonov street, Moscow, 129226
O. N. Tkacheva
Pirogov Russian National Research Medical University of Ministry of Health of Russian federation Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
Olga N. Tkacheva - MD, PhD, DSc, Professor, Director.
MoscowL. V. Matchekhina
Pirogov Russian National Research Medical University of Ministry of Health of Russian federation Russian Gerontology Research and Clinical Centre
Lyubov V. Matchekhina - MD, PhD, Researcher, Laboratory of the Age-related Metabolic and Endocrine Disorders.
Moscow
Yu. V. Kotovskaya
Pirogov Russian National Research Medical University of Ministry of Health of Russian federation Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
Yulia V. Kotovskaya - MD, PhD, DSc, Professor, Deputy Director on Research.
Moscow
I. V. Leonteva
Pirogov Russian National Research Medical University of Ministry of Health of Russian federation The Research and Clinical Institute for Pediatrics named after Academician Yuri Veltischev
Russian Federation
Russian Federation
Irina V. Leontieva - MD, PhD, DSc, Professor, Leading Researcher, Department of Peadiatrics Cardiology and Arrhythmology.
Moscow
I. A. Kovalev
Pirogov Russian National Research Medical University of Ministry of Health of Russian federation The Research and Clinical Institute for Pediatrics named after Academician Yuri Veltischev
Russian Federation
Russian Federation
Igor A. Kovalev - MD, PhD, DSc, Professor, Head, Department of Peadiatrics Cardiology and Arrhythmology.
Moscow
M. A. Shkolnikova
Pirogov Russian National Research Medical University of Ministry of Health of Russian federation The Research and Clinical Institute for Pediatrics named after Academician Yuri Veltischev
Maria A. Shkolnikova - MD, PhD, DSc, Professor, Research Leader.
Moscow
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Review
For citations:
Dudinskaya E.N., Tkacheva O.N., Matchekhina L.V., Kotovskaya Yu.V., Leonteva I.V., Kovalev I.A., Shkolnikova M.A. Replicative cell ageing: the role of insulin resistance in patients with arterial hypertension. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2019;25(3):225-231. (In Russ.) https://doi.org/10.18705/1607-419X-2019-25-3-225-231
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