NR2-антитела как диагностический и прогностический биомаркер при инсульте

Учитывая высокий процент инвалидизации и смертности в результате перенесенного инсульта, в настоящее время является перспективным поиск новых возможностей для улучшения ранней диагностики и оптимизации терапевтических подходов. В статье представлен обзор литературы, посвященной изучению NR2-антител к глутаматным N-метил-D-аспартат (NMDA) рецепторам в качестве биомаркера в остром периоде инсульта. Проведенный обзор показал, что данный биомаркер пригоден для определения наличия ишемического процесса в мозге и степени разрушения мозговой ткани, как в первые часы инсульта, так и в динамике. Кроме того, анализ NR2-антител может быть информативен для контроля за течением заболевания в случае увеличения размеров очага, что может способствовать своевременной коррекции лечения и позволит улучшить эффективность проводимой терапии. Важным параметром можно считать прогностический потенциал NR2-антител, что может быть использовано для оптимизации персонифицированного терапевтического подхода. Однако малочисленность исследований NR2-антител в остром периоде инсульта на сегодняшний день требует дальнейшего изучения данного биомаркера.

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